Synthesis of novel silver-loaded clay AgF@Hec for the prevention of dental cariesin vitro.
Biomed Mater
; 19(4)2024 Jun 20.
Article
in En
| MEDLINE
| ID: mdl-38810617
ABSTRACT
Dental caries, a chronic infectious disease characterized by tooth mineral loss caused by plaque, is one of the major global public health problems. Silver diamine fluoride (SDF) has been proven to be a highly effective anti-caries drug due to its high bacterial inhibition and remineralization ability. However, the SDF solution is unstable, which immensely limits its clinical application. Therefore, new silver-load clay named AgF@Hec was designed by replacing the NH3with hectorite in this study. Fourier transform infrared spectroscopy and x-ray diffraction spectroscopy were employed to confirm the structure of AgF@Hec. Dynamic light scattering analysis was used to reveal the effect of different hectorite concentrations on the stability of AgF@Hec. Moreover, AgF@Hec exhibits significant remineralization and hardness recovery of the initial carious lesions. Bacteriostatic experiments also proved that it has a significant inhibitory effect onA. Viscosus, S. mutans, S. sanguinis, S. salivarius, Lactobacillus sp.and both gram-positive and gram-negative bacteria. We therefore believed that AgF@Hec should be a promising biomaterial that can be applied in the prevention of dental caries.
Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Silver
/
X-Ray Diffraction
/
Clay
/
Silver Compounds
/
Dental Caries
/
Quaternary Ammonium Compounds
Limits:
Animals
/
Humans
Language:
En
Journal:
Biomed Mater
Journal subject:
ENGENHARIA BIOMEDICA
Year:
2024
Document type:
Article