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Prognostic factors and survival disparities in right-sided versus left-sided colon cancer.
Asghari-Jafarabadi, Mohammad; Wilkins, Simon; Plazzer, John Paul; Yap, Raymond; McMurrick, Paul John.
Affiliation
  • Asghari-Jafarabadi M; Cabrini Research, Cabrini Hospital, Malvern, VIC, 3144, Australia.
  • Wilkins S; School of Public Health and Preventive Medicine, Monash University, Melbourne, VIC, 3004, Australia.
  • Plazzer JP; Department of Psychiatry, School of Clinical Sciences, Monash University, Clayton, VIC, 3168, Australia.
  • Yap R; Cabrini Monash University Department of Surgery, Cabrini Hospital, 183 Wattletree Road, Malvern, VIC, 3144, Australia. simonwilkins@cabrini.com.au.
  • McMurrick PJ; Department of Biochemistry and Molecular Biology, Monash University, Melbourne, VIC, 3800, Australia. simonwilkins@cabrini.com.au.
Sci Rep ; 14(1): 12306, 2024 05 29.
Article in En | MEDLINE | ID: mdl-38811769
ABSTRACT
Right-sided colon cancer (RCC) and left-sided colon cancer (LCC) differ in features and outcomes because of variations in embryology, epidemiology, pathology, and prognosis. This study sought to identify significant factors impacting patient survival through Bayesian modelling. Data was retrospectively analysed from a colorectal neoplasia database. Data on demographics, perioperative risks, treatment, mortality, and survival was analysed from patients who underwent colon cancer surgery from January 2010 to December 2021. This study involved 2475 patients, with 58.7% having RCC and 41.3% having LCC. RCC patients had a notably higher mortality rate, and their overall survival (OS) rates were slightly lower than those with LCC (P < 0.05). RCC stages I-IV consistently exhibited worse OS and relapse-free survival (RFS) than LCC (P < 0.05). Factors like age, BMI, ASA score, cancer stage, and comorbidities had significant associations with OS and RFS. Poor and moderate differentiation, lower lymph node yield, and organ resection were linked to lower survival while receiving chemotherapy; higher BMI levels and elective surgery were associated with better survival (all P < 0.05). Our study reveals key differences between RCC and LCC, emphasising the impact of age, BMI, ASA score, cancer stage, and comorbidities on patient survival. These findings could inform personalised treatment strategies for colon cancer patients.
Subject(s)

Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Colonic Neoplasms Limits: Adult / Aged / Aged80 / Female / Humans / Male / Middle aged Language: En Journal: Sci Rep Year: 2024 Document type: Article Affiliation country: Australia

Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Colonic Neoplasms Limits: Adult / Aged / Aged80 / Female / Humans / Male / Middle aged Language: En Journal: Sci Rep Year: 2024 Document type: Article Affiliation country: Australia