Biosynthesis of macrolactam antibiotics with ß-amino acid polyketide starter units.
J Antibiot (Tokyo)
; 77(8): 486-498, 2024 Aug.
Article
in En
| MEDLINE
| ID: mdl-38816450
ABSTRACT
Macrolactam antibiotics incorporating ß-amino acid polyketide starter units, isolated primarily from Actinomycetes species, show significant biological activities. This review provides a detailed analysis into the biosynthetic studies of vicenistatin, a macrolactam antibiotic with a 3-aminoisobutyrate starter unit, as well as biosynthetic research on related macrolactam compounds. Firstly, the elucidation of a common mechanism for the incorporation of ß-amino acid starter units into the polyketide synthase (PKS) is described. Secondly, the unique biosynthetic mechanisms of the ß-amino acids that are used to supply the main macrolactam biosynthetic pathways with starter units are discussed. Thirdly, some distinctive post-PKS modification mechanisms that complete macrolactam antibiotic biosynthesis are summarized. Finally, future directions for creating new macrolactam compounds through engineered biosynthesis pathways are described.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Polyketide Synthases
/
Polyketides
/
Amino Acids
/
Anti-Bacterial Agents
Language:
En
Journal:
J Antibiot (Tokyo)
Year:
2024
Document type:
Article
Affiliation country:
Japan
Country of publication:
United kingdom