Molecular Pathology of Myeloid Neoplasms: Molecular Pattern Recognition.
Clin Lab Med
; 44(2): 339-353, 2024 Jun.
Article
in En
| MEDLINE
| ID: mdl-38821648
ABSTRACT
Despite the apparent complexity of the molecular genetic underpinnings of myeloid neoplasms, most myeloid mutational profiles can be understood within a simple framework. Somatic mutations accumulate in hematopoietic stem cells with aging and toxic insults, termed clonal hematopoiesis. These "old stem cells" mutations, predominantly in the epigenetic and RNA spliceosome pathways, act as "founding" driver mutations leading to a clonal myeloid neoplasm when sufficient in number and clone size. Subsequent mutations can create the genetic flavor of the myeloid neoplasm ("backseat" drivers) due to their enrichment in certain entities or act as progression events ("aggressive" drivers) during clonal evolution.
Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Myelodysplastic Syndromes
/
Myeloproliferative Disorders
Limits:
Humans
Language:
En
Journal:
Clin Lab Med
Year:
2024
Document type:
Article
Affiliation country:
United States
Country of publication:
United States