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Ovarian aging: energy metabolism of oocytes.
Bao, Shenglan; Yin, Tailang; Liu, Su.
Affiliation
  • Bao S; Reproductive Medical Center, Renmin Hospital of Wuhan University, Wuhan, China.
  • Yin T; Reproductive Medical Center, Renmin Hospital of Wuhan University, Wuhan, China. reproductive@whu.edu.cn.
  • Liu S; Shenzhen Key Laboratory of Reproductive Immunology for Peri-Implantation, , Shenzhen Zhongshan Institute for Reproductive Medicine and Genetics, Shenzhen Zhongshan Obstetrics & Gynecology Hospital (Formerly Shenzhen Zhongshan Urology Hospital), Shenzhen, China. sunnysue0309@163.com.
J Ovarian Res ; 17(1): 118, 2024 May 31.
Article in En | MEDLINE | ID: mdl-38822408
ABSTRACT
In women who are getting older, the quantity and quality of their follicles or oocytes and decline. This is characterized by decreased ovarian reserve function (DOR), fewer remaining oocytes, and lower quality oocytes. As more women choose to delay childbirth, the decline in fertility associated with age has become a significant concern for modern women. The decline in oocyte quality is a key indicator of ovarian aging. Many studies suggest that age-related changes in oocyte energy metabolism may impact oocyte quality. Changes in oocyte energy metabolism affect adenosine 5'-triphosphate (ATP) production, but how related products and proteins influence oocyte quality remains largely unknown. This review focuses on oocyte metabolism in age-related ovarian aging and its potential impact on oocyte quality, as well as therapeutic strategies that may partially influence oocyte metabolism. This research aims to enhance our understanding of age-related changes in oocyte energy metabolism, and the identification of biomarkers and treatment methods.
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Oocytes / Ovary / Aging / Energy Metabolism Limits: Animals / Female / Humans Language: En Journal: J Ovarian Res Year: 2024 Document type: Article Affiliation country: China

Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Oocytes / Ovary / Aging / Energy Metabolism Limits: Animals / Female / Humans Language: En Journal: J Ovarian Res Year: 2024 Document type: Article Affiliation country: China