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Add-On Deep Brain Stimulation versus Continued Vagus Nerve Stimulation for Childhood Epilepsy (ADVANCE): A Partially Randomized Patient Preference Trial.
Suresh, Hrishikesh; Mithani, Karim; Warsi, Nebras; Ochi, Ayako; Otsubo, Hiroshi; Drake, James M; Rutka, James T; Kerr, Elizabeth; Smith, Mary Lou; Breitbart, Sara; Yau, Ivanna; McRae, Lyndsey; Chau, Vann; Weiss, Shelly; Jain, Puneet; Donner, Elizabeth; Fasano, Alfonso; Gorodetsky, Carolina; Ibrahim, George M.
Affiliation
  • Suresh H; Institute of Biomedical Engineering, University of Toronto, Toronto, ON, Canada.
  • Mithani K; Program in Neuroscience and Mental Health, The Hospital for Sick Children Research Institute, Toronto, ON, Canada.
  • Warsi N; Division of Neurosurgery, Department of Surgery, University of Toronto, Toronto, ON, Canada.
  • Ochi A; Institute of Biomedical Engineering, University of Toronto, Toronto, ON, Canada.
  • Otsubo H; Program in Neuroscience and Mental Health, The Hospital for Sick Children Research Institute, Toronto, ON, Canada.
  • Drake JM; Division of Neurosurgery, Department of Surgery, University of Toronto, Toronto, ON, Canada.
  • Rutka JT; Institute of Biomedical Engineering, University of Toronto, Toronto, ON, Canada.
  • Kerr E; Program in Neuroscience and Mental Health, The Hospital for Sick Children Research Institute, Toronto, ON, Canada.
  • Smith ML; Division of Neurosurgery, Department of Surgery, University of Toronto, Toronto, ON, Canada.
  • Breitbart S; Division of Neurology, The Hospital for Sick Children, Toronto, ON, Canada.
  • Yau I; Division of Neurology, The Hospital for Sick Children, Toronto, ON, Canada.
  • McRae L; Division of Neurosurgery, Department of Surgery, University of Toronto, Toronto, ON, Canada.
  • Chau V; Division of Neurosurgery, The Hospital for Sick Children, Toronto, ON, Canada.
  • Weiss S; Division of Neurosurgery, Department of Surgery, University of Toronto, Toronto, ON, Canada.
  • Jain P; Division of Neurosurgery, The Hospital for Sick Children, Toronto, ON, Canada.
  • Donner E; Division of Neurology, The Hospital for Sick Children, Toronto, ON, Canada.
  • Fasano A; Program in Neuroscience and Mental Health, The Hospital for Sick Children Research Institute, Toronto, ON, Canada.
  • Gorodetsky C; Division of Neurology, The Hospital for Sick Children, Toronto, ON, Canada.
  • Ibrahim GM; Division of Neurosurgery, The Hospital for Sick Children, Toronto, ON, Canada.
Ann Neurol ; 96(2): 405-411, 2024 Aug.
Article in En | MEDLINE | ID: mdl-38822686
ABSTRACT
Outcomes following vagus nerve stimulation (VNS) improve over years after implantation in children with drug-resistant epilepsy. The added value of deep brain stimulation (DBS) instead of continued VNS optimization is unknown. In a prospective, non-blinded, randomized patient preference trial of 18 children (aged 8-17 years) who did not respond to VNS after at least 1 year, add-on DBS resulted in greater seizure reduction compared with an additional year of VNS optimization (51.9% vs. 12.3%, p = 0.047). Add-on DBS also resulted in less bothersome seizures (p = 0.03), but no change in quality of life. DBS may be considered earlier for childhood epilepsy after non-response to VNS. ANN NEUROL 2024;96405-411.
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Deep Brain Stimulation / Vagus Nerve Stimulation / Patient Preference / Drug Resistant Epilepsy Limits: Adolescent / Child / Female / Humans / Male Language: En Journal: Ann Neurol Year: 2024 Document type: Article Affiliation country: Canada Country of publication: United States
Fulltext
Add to My VHL
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PubMed Links
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Deep Brain Stimulation / Vagus Nerve Stimulation / Patient Preference / Drug Resistant Epilepsy Limits: Adolescent / Child / Female / Humans / Male Language: En Journal: Ann Neurol Year: 2024 Document type: Article Affiliation country: Canada Country of publication: United States