Madhuca indica oil-entrapped buoyant galactomannan hydrogel microspheres for controlling epileptic seizures.
Int J Biol Macromol
; 272(Pt 1): 132739, 2024 Jun.
Article
in En
| MEDLINE
| ID: mdl-38825290
ABSTRACT
A stable Madhuca indica oil-in-water nanoemulsion (99-210 nm, zeta potential > - 30 mV) was produced employing Tween 20 (surfactant) and Transcutol P (co-surfactant) (31). The nanoemulsion (oil Smix = 37, 55, and 73) were subsequently incorporated into oxcarbazepine-loaded carboxymethylxanthan gum (DS = 1.23) dispersion. The hydrogel microspheres were formed using the ionic gelation process. Higher oil concentration had a considerable impact on particle size, drug entrapment efficiency, and buoyancy. The maximum 92 % drug entrapment efficiency was achieved with the microspheres having oil Smix ratio 55. FESEM study revealed that the microspheres were spherical in shape and had an orange peel-like surface roughness. FTIR analysis revealed a hydrogen bonding interaction between drug and polymer. Thermal and x-ray examinations revealed the transformation of crystalline oxcarbazepine into an amorphous form. The microspheres had a buoyancy period of 7.5 h with corresponding release of around 83 % drug in 8 h in simulated stomach fluid, governed by supercase-II transport mechanism. In vivo neurobehavioral studies on PTZ-induced rats demonstrated that the microspheres outperformed drug suspension in terms of rotarod retention, number of crossings, and rearing activity in open field. Thus, Madhuca indica oil-in-water nanoemulsion-entrapped carboxymethyl xanthan gum microspheres appeared to be useful for monitoring oxcarbazepine release and managing epileptic seizures.
Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Mannans
/
Microspheres
Limits:
Animals
Language:
En
Journal:
Int J Biol Macromol
Year:
2024
Document type:
Article
Affiliation country:
India