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Anticancer nano-prodrugs with drug release triggered by intracellular dissolution and hydrogen peroxide response.
Shibata, Aki; Koseki, Yoshitaka; Tanita, Keita; Kitajima, Showa; Oka, Kouki; Maruoka, Kiyotaka; Suzuki, Ryuju; Thi Ngoc Dao, Anh; Kasai, Hitoshi.
Affiliation
  • Shibata A; Institute of Multidisciplinary Research for Advanced Materials, Tohoku University, 2-1-1 Katahira, Aoba-ku, Sendai-shi, Miyagi-ken 980-8577, Japan. koseki@tohoku.ac.jp.
  • Koseki Y; Institute of Multidisciplinary Research for Advanced Materials, Tohoku University, 2-1-1 Katahira, Aoba-ku, Sendai-shi, Miyagi-ken 980-8577, Japan. koseki@tohoku.ac.jp.
  • Tanita K; Institute of Multidisciplinary Research for Advanced Materials, Tohoku University, 2-1-1 Katahira, Aoba-ku, Sendai-shi, Miyagi-ken 980-8577, Japan. koseki@tohoku.ac.jp.
  • Kitajima S; Institute of Multidisciplinary Research for Advanced Materials, Tohoku University, 2-1-1 Katahira, Aoba-ku, Sendai-shi, Miyagi-ken 980-8577, Japan. koseki@tohoku.ac.jp.
  • Oka K; Institute of Multidisciplinary Research for Advanced Materials, Tohoku University, 2-1-1 Katahira, Aoba-ku, Sendai-shi, Miyagi-ken 980-8577, Japan. koseki@tohoku.ac.jp.
  • Maruoka K; Institute of Multidisciplinary Research for Advanced Materials, Tohoku University, 2-1-1 Katahira, Aoba-ku, Sendai-shi, Miyagi-ken 980-8577, Japan. koseki@tohoku.ac.jp.
  • Suzuki R; National Institute of Technology, Sendai College, 48 Nodayama, Medeshima-Shiote, Natori-shi, Miyagi-ken 981-1239, Japan.
  • Thi Ngoc Dao A; Graduated School of Integrated Science and Technology, Nagasaki University, 1-14 Bunkyo-machi, Nagasaki-shi, Nagasaki-ken 852-8521, Japan.
  • Kasai H; Institute of Multidisciplinary Research for Advanced Materials, Tohoku University, 2-1-1 Katahira, Aoba-ku, Sendai-shi, Miyagi-ken 980-8577, Japan. koseki@tohoku.ac.jp.
Chem Commun (Camb) ; 60(50): 6427-6430, 2024 Jun 18.
Article in En | MEDLINE | ID: mdl-38829169
ABSTRACT
We developed prodrug nanoparticles that release drugs through intracellular dissolution and a cancer-specific hydrogen peroxide response. To reveal the unclear mechanism regarding drug release from nanoparticles by reacting with hydrogen peroxide in cancer cells, this study demonstrates the in vitro evaluation of drug release kinetics under conditions simulated in cancer cells.
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Prodrugs / Nanoparticles / Drug Liberation / Hydrogen Peroxide / Antineoplastic Agents Limits: Humans Language: En Journal: Chem Commun (Camb) Journal subject: QUIMICA Year: 2024 Document type: Article Affiliation country: Japan Publication country: ENGLAND / ESCOCIA / GB / GREAT BRITAIN / INGLATERRA / REINO UNIDO / SCOTLAND / UK / UNITED KINGDOM
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Prodrugs / Nanoparticles / Drug Liberation / Hydrogen Peroxide / Antineoplastic Agents Limits: Humans Language: En Journal: Chem Commun (Camb) Journal subject: QUIMICA Year: 2024 Document type: Article Affiliation country: Japan Publication country: ENGLAND / ESCOCIA / GB / GREAT BRITAIN / INGLATERRA / REINO UNIDO / SCOTLAND / UK / UNITED KINGDOM