Intestinal cDC1s provide cues required for CD4+ T cell-mediated resistance to Cryptosporidium.
J Exp Med
; 221(7)2024 Jul 01.
Article
in En
| MEDLINE
| ID: mdl-38829369
ABSTRACT
Cryptosporidium is an enteric pathogen and a prominent cause of diarrheal disease worldwide. Control of Cryptosporidium requires CD4+ T cells, but how protective CD4+ T cell responses are generated is poorly understood. Here, Cryptosporidium parasites that express MHCII-restricted model antigens were generated to understand the basis for CD4+ T cell priming and effector function. These studies revealed that parasite-specific CD4+ T cells are primed in the draining mesenteric lymph node but differentiate into Th1 cells in the gut to provide local parasite control. Although type 1 conventional dendritic cells (cDC1s) were dispensable for CD4+ T cell priming, they were required for CD4+ T cell gut homing and were a source of IL-12 at the site of infection that promoted local production of IFN-γ. Thus, cDC1s have distinct roles in shaping CD4+ T cell responses to an enteric infection first, to promote gut homing from the mesLN, and second, to drive effector responses in the intestine.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Dendritic Cells
/
CD4-Positive T-Lymphocytes
/
Cryptosporidiosis
/
Cryptosporidium
/
Mice, Inbred C57BL
Limits:
Animals
Language:
En
Journal:
J Exp Med
Year:
2024
Document type:
Article
Affiliation country:
United States
Country of publication:
United States