Unraveling the Mechanisms of Cannabidiol's Pharmacological Actions: A Comprehensive Research Overview.
Top Curr Chem (Cham)
; 382(2): 20, 2024 Jun 03.
Article
in En
| MEDLINE
| ID: mdl-38829467
ABSTRACT
Cannabis sativa has long been used for neurological and psychological healing. Recently, cannabidiol (CBD) extracted from cannabis sativa has gained prominence in the medical field due to its non-psychotropic therapeutic effects on the central and peripheral nervous systems. CBD, also acting as a potent antioxidant, displays diverse clinical properties such as anticancer, antiinflammatory, antidepressant, antioxidant, antiemetic, anxiolytic, antiepileptic, and antipsychotic effects. In this review, we summarized the structural activity relationship of CBD with different receptors by both experimental and computational techniques and investigated the mechanism of interaction between related receptors and CBD. The discovery of structural activity relationship between CBD and target receptors would provide a direction to optimize the scaffold of CBD and its derivatives, which would give potential medical applications on CBD-based therapies in various illnesses.
Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Cannabidiol
Limits:
Animals
/
Humans
Language:
En
Journal:
Top Curr Chem (Cham)
Year:
2024
Document type:
Article
Affiliation country:
China