Systematic review and meta-analysis: Evaluating the influence of intrahepatic cholestasis of pregnancy on obstetric and neonatal outcomes.
PLoS One
; 19(6): e0304604, 2024.
Article
in En
| MEDLINE
| ID: mdl-38833446
ABSTRACT
BACKGROUND:
Intrahepatic cholestasis of pregnancy (ICP) is a serious liver conditions that negatively impacts obstetric and neonatal outcomes. Elevated levels of bile acid, particularly glycine conjugate, may compromise blood flow and cause functional hypoxia-ischemia.AIMS:
This meta-analysis aims to assess the association between ICP and key pregnancy outcomes including emergency caesarian sections (C-sections), preeclampsia, hemorrhage, preterm birth, small for gestational age, admission rate to neonatal intensive care union (NICU), gestational age, and stillbirth. MATERIALS ANDMETHODS:
Literature search across five databases (PubMed, Embase, Web of Science) was done to detect relevant studies published up until June 2023. Meta-analysis of the identified studies was done using a random-effects model, and the results presented as Odds ratio (OR).RESULTS:
A literature search identified 662 studies. Of them, 21 met the inclusion criteria. There was a significant association between ICP and odds of C-section (OR 1.42, p <0.001), preeclampsia (OR 2.64, p <0.001), NICU admission (OR 2.1, p <0.001), and pre-term birth (OR 2.64, p <0.001). ICP was not associated with postpartum hemmorhage (OR 1.31, p = 0.13), small for gestational age (OR 0.87, p = 0.07), stillbirth (OR 1.49, p = 0.29).CONCLUSIONS:
Our results confirm the adverse effects of ICP on co-existing pregnancy complications, obstetric and neonatal outcomes. ICP in associated with severe complications including increased rates of preeclampsia, emergency C-sections, preterm births, l gestational periods and higher rates of NICU admissions. These results may assist healthcare professionals in formulating comprehensive care guidelines for expectant mothers and newborns.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Pregnancy Complications
/
Pregnancy Outcome
/
Cholestasis, Intrahepatic
/
Premature Birth
Limits:
Female
/
Humans
/
Newborn
/
Pregnancy
Language:
En
Journal:
PLoS One
Journal subject:
CIENCIA
/
MEDICINA
Year:
2024
Document type:
Article
Affiliation country:
China