Synthesis and Evaluation of a Cathepsin B-Recognizing Trifunctional Chelating Agent to Improve Tumor Retention of Radioimmunoconjugates.

Jinda, Hiroki; Nakashima, Kazuma; Watanabe, Hiroyuki; Ono, Masahiro

Jinda, Hiroki; Nakashima, Kazuma; Watanabe, Hiroyuki; Ono, Masahiro.

Affiliation

Jinda H; Department of Patho-Functional Bioanalysis, Graduate School of Pharmaceutical Sciences, Kyoto University, Kyoto, Japan.
Nakashima K; Department of Patho-Functional Bioanalysis, Graduate School of Pharmaceutical Sciences, Kyoto University, Kyoto, Japan.
Watanabe H; Department of Patho-Functional Bioanalysis, Graduate School of Pharmaceutical Sciences, Kyoto University, Kyoto, Japan.
Ono M; Department of Patho-Functional Bioanalysis, Graduate School of Pharmaceutical Sciences, Kyoto University, Kyoto, Japan.

J Labelled Comp Radiopharm ; 67(8): 295-304, 2024 Jun 30.

Article in En | MEDLINE | ID: mdl-38837480

Subject(s)

Cathepsin B; Chelating Agents; Immunoconjugates; Cathepsin B/metabolism; Chelating Agents/chemistry; Chelating Agents/chemical synthesis; Animals; Mice; Immunoconjugates/chemistry; Immunoconjugates/pharmacokinetics; Tissue Distribution; Cell Line, Tumor; Humans; Indium Radioisotopes/chemistry; Chemistry Techniques, Synthetic; Trastuzumab/chemistry

Key words

cathepsin B (CTSB); radioimmunoconjugate (RIC); radiometabolite; tumor retention

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Cathepsin B / Chelating Agents / Immunoconjugates Limits: Animals / Humans Language: En Journal: J Labelled Comp Radiopharm Year: 2024 Document type: Article Affiliation country: Japan Country of publication: United kingdom

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