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Pioneering cord blood transplantation in relapsed/refractory HIV-related lymphoma: a case study with concurrent intramuscular antiretroviral therapy.
Yokota, Takako; Kurosawa, Shuhei; Yoshimura, Yukihiro; Bingo, Masato; Yamaguchi, Tomoko; Takada, Yusuke; So, Yuna; Miyata, Nobuyuki; Nakayama, Hitomi; Sakurai, Aki; Sato, Kosuke; Ito, Chisako; Aisa, Yoshinobu; Nakazato, Tomonori.
Affiliation
  • Yokota T; Department of Hematology, Yokohama Municipal Citizen's Hospital, Yokohama, Kanagawa, Japan.
  • Kurosawa S; Department of Hematology, Yokohama Municipal Citizen's Hospital, Yokohama, Kanagawa, Japan. Electronic address: 1a.4ftnn6@gmail.com.
  • Yoshimura Y; Division of Infectious Disease, Yokohama Municipal Citizen's Hospital, Yokohama, Kanagawa, Japan.
  • Bingo M; Department of Laboratory Medicine, Tokyo Medical University Hospital, Shinjuku, Tokyo, Japan.
  • Yamaguchi T; Department of Laboratory Medicine, Tokyo Medical University Hospital, Shinjuku, Tokyo, Japan.
  • Takada Y; Department of Hematology, Yokohama Municipal Citizen's Hospital, Yokohama, Kanagawa, Japan.
  • So Y; Division of Infectious Disease, Yokohama Municipal Citizen's Hospital, Yokohama, Kanagawa, Japan.
  • Miyata N; Division of Infectious Disease, Yokohama Municipal Citizen's Hospital, Yokohama, Kanagawa, Japan.
  • Nakayama H; Department of Hematology, Yokohama Municipal Citizen's Hospital, Yokohama, Kanagawa, Japan.
  • Sakurai A; Department of Hematology, Yokohama Municipal Citizen's Hospital, Yokohama, Kanagawa, Japan.
  • Sato K; Division of Infectious Disease, Yokohama Municipal Citizen's Hospital, Yokohama, Kanagawa, Japan.
  • Ito C; Department of Hematology, Yokohama Municipal Citizen's Hospital, Yokohama, Kanagawa, Japan.
  • Aisa Y; Department of Hematology, Yokohama Municipal Citizen's Hospital, Yokohama, Kanagawa, Japan.
  • Nakazato T; Department of Hematology, Yokohama Municipal Citizen's Hospital, Yokohama, Kanagawa, Japan.
Int J Infect Dis ; 146: 107124, 2024 Sep.
Article in En | MEDLINE | ID: mdl-38838848
ABSTRACT
A 44-year-old HIV-positive man diagnosed with diffuse large B-cell lymphoma in 2021 achieved complete remission with six cycles of R-CHOP therapy but had a relapse in November 2022. ESHAP therapy failed to induce remission, leading to complete remission with four cycles of Pola-BR therapy. Post-failure of autologous stem cell harvest, cord blood transplantation (CBT) was performed in June 2023. Notably, this case used recently approved intramuscular antiretroviral therapy (ART) with cabotegravir and rilpivirine, addressing gastrointestinal complications during CBT. This innovative use of intramuscular ART in the treatment of malignancy represents a first in the field, offering a pioneering approach to HIV-related lymphoma.
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: HIV Infections / Lymphoma, Large B-Cell, Diffuse / Cord Blood Stem Cell Transplantation Limits: Adult / Humans / Male Language: En Journal: Int J Infect Dis Journal subject: DOENCAS TRANSMISSIVEIS Year: 2024 Document type: Article Affiliation country: Japan Country of publication: Canada
Fulltext
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: HIV Infections / Lymphoma, Large B-Cell, Diffuse / Cord Blood Stem Cell Transplantation Limits: Adult / Humans / Male Language: En Journal: Int J Infect Dis Journal subject: DOENCAS TRANSMISSIVEIS Year: 2024 Document type: Article Affiliation country: Japan Country of publication: Canada