Human laboratory models of reward in substance use disorder.
Pharmacol Biochem Behav
; 241: 173803, 2024 Aug.
Article
in En
| MEDLINE
| ID: mdl-38843997
ABSTRACT
Human laboratory models in substance use disorder provide a key intermediary step between highly controlled and mechanistically informative non-human preclinical methods and clinical trials conducted in human populations. Much like preclinical models, the variety of human laboratory methods provide insights into specific features of substance use disorder rather than modelling the diverse causes and consequences simultaneously in a single model. This narrative review provides a discussion of popular models of reward used in human laboratory research on substance use disorder with a focus on the specific contributions that each model has towards informing clinical outcomes (forward translation) and analogs within preclinical models (backward translation). Four core areas of human laboratory research are discussed drug self-administration, subjective effects, behavioral economics, and cognitive and executive function. Discussion of common measures and models used, the features of substance use disorder that these methods are purported to evaluate, unique issues for measure validity and application, and translational links to preclinical models and special considerations for studies wishing to evaluate homology across species is provided.
Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Reward
/
Self Administration
/
Substance-Related Disorders
Limits:
Animals
/
Humans
Language:
En
Journal:
Pharmacol Biochem Behav
Year:
2024
Document type:
Article
Affiliation country:
United States
Country of publication:
United States