IgA multiple myeloma-associated mediastinal spinal plasmacytoma presenting as spinal cord compression.
BMJ Case Rep
; 17(6)2024 Jun 06.
Article
in En
| MEDLINE
| ID: mdl-38844357
ABSTRACT
Multiple myeloma associated with extramedullary plasmacytoma at initial presentation is rare. We describe a case of a man in his 30s who initially presented with symptoms of spinal cord compression. Further imaging revealed a mediastinal tumour, with a biopsy confirming plasmacytoma. Immunofixation revealed IgA lambda paraprotein. Bone marrow biopsy demonstrated atypical T-cell cytotoxic proliferation and trilineage hypoplasia. The patient was diagnosed with extramedullary plasmacytoma with active IgA multiple myeloma. The patient received mediastinal radiation to the tumour, followed by anti-myeloma therapy. This diagnosis is critical as managing a solitary plasmacytoma drastically differs from an extramedullary plasmacytoma with active multiple myeloma.
Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Plasmacytoma
/
Spinal Cord Compression
/
Immunoglobulin A
/
Mediastinal Neoplasms
/
Multiple Myeloma
Limits:
Adult
/
Humans
/
Male
Language:
En
Journal:
BMJ Case Rep
Year:
2024
Document type:
Article
Affiliation country:
United States
Country of publication:
United kingdom