Flavonoids and post haemorrhoidectomy recovery: a systematic review and meta-analysis.
ANZ J Surg
; 94(9): 1480-1490, 2024 Sep.
Article
in En
| MEDLINE
| ID: mdl-38847122
ABSTRACT
BACKGROUND:
Haemorrhoidectomy is the gold standard for definitive treatment of high-grade symptomatic haemorrhoids but is often associated with substantial pain. This systematic review aims to explore the potential of flavonoids in alleviating the postoperative symptom burden following excisional haemorrhoidectomy.METHODS:
A systematic review of the literature was conducted according to Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines (PROSPERO CRD42023472711). Randomized controlled trials (RCTs) published PubMed, MEDLINE, Embase, and Scopus from inception to 1st December 2023 were retrieved. The primary outcome investigated was post-operative pain. Meta-analysis was performed using Review Manager version 5.4.1.RESULTS:
Ten articles with 775 patients were included. The meta-analysis identified statistically significant decreases in post-operative pain in favour of the flavonoid groups (Standardized Mean Difference -0.66 [95% confidence intervals (CI) -0.82, -0.52]; P < 0.00001), and bleeding (Odds Ratio 0.13 [95% CI 0.09, 0.19]; P < 0.00001).CONCLUSION:
Flavonoids show promise as a means of reducing pain associated with excisional haemorrhoidectomy. Further research is required to investigate topical routes of administration and standardize regimes.Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Pain, Postoperative
/
Flavonoids
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Hemorrhoidectomy
/
Hemorrhoids
Limits:
Humans
Language:
En
Journal:
ANZ J Surg
Year:
2024
Document type:
Article
Affiliation country:
New Zealand
Country of publication:
Australia