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Positive Associations of Perfluoroalkyl and Polyfluoroalkyl Substances With Hypertension May Be Attenuated by Endogenous Sex Hormones: A Nationally Representative Cross-Sectional Study.
Wu, Bing; Sheng, Nan; Li, Zheng; Wang, Jinghua; Ji, Saisai; Zhao, Feng; Pan, Yitao; Qu, Yingli; Wei, Yuan; Xie, Linna; Li, Yawei; Hu, Xiaojian; Wu, Changzi; Zhang, Zheng; Qiu, Yidan; Zheng, Xulin; Zhang, Wenli; Hu, Xuehua; Song, Haocan; Cai, Jiayi; Cao, Zhaojin; Ji, John S; Lv, Yuebin; Dai, Jiayin; Shi, Xiaoming.
Affiliation
  • Wu B; China CDC Key Laboratory of Environment and Population Health, National Institute of Environmental Health, Chinese Center for Disease Control and Prevention, Beijing (B.W., Z.L., S.J., F.Z., Y.Q., Y.W., L.X., Y.L., X.H., C.W., Z.Z., Y.Q., X.Z., W.Z., X.H., H.S., J.C., Z.C., Y.L., X.S.).
  • Sheng N; State Environmental Protection Key Laboratory of Environmental Health Impact Assessment of Emerging Contaminants, School of Environmental Science and Engineering, Shanghai Jiao Tong University, China (N.S., J.W., Y.P., J.D.).
  • Li Z; China CDC Key Laboratory of Environment and Population Health, National Institute of Environmental Health, Chinese Center for Disease Control and Prevention, Beijing (B.W., Z.L., S.J., F.Z., Y.Q., Y.W., L.X., Y.L., X.H., C.W., Z.Z., Y.Q., X.Z., W.Z., X.H., H.S., J.C., Z.C., Y.L., X.S.).
  • Wang J; State Environmental Protection Key Laboratory of Environmental Health Impact Assessment of Emerging Contaminants, School of Environmental Science and Engineering, Shanghai Jiao Tong University, China (N.S., J.W., Y.P., J.D.).
  • Ji S; China CDC Key Laboratory of Environment and Population Health, National Institute of Environmental Health, Chinese Center for Disease Control and Prevention, Beijing (B.W., Z.L., S.J., F.Z., Y.Q., Y.W., L.X., Y.L., X.H., C.W., Z.Z., Y.Q., X.Z., W.Z., X.H., H.S., J.C., Z.C., Y.L., X.S.).
  • Zhao F; China CDC Key Laboratory of Environment and Population Health, National Institute of Environmental Health, Chinese Center for Disease Control and Prevention, Beijing (B.W., Z.L., S.J., F.Z., Y.Q., Y.W., L.X., Y.L., X.H., C.W., Z.Z., Y.Q., X.Z., W.Z., X.H., H.S., J.C., Z.C., Y.L., X.S.).
  • Pan Y; State Environmental Protection Key Laboratory of Environmental Health Impact Assessment of Emerging Contaminants, School of Environmental Science and Engineering, Shanghai Jiao Tong University, China (N.S., J.W., Y.P., J.D.).
  • Qu Y; China CDC Key Laboratory of Environment and Population Health, National Institute of Environmental Health, Chinese Center for Disease Control and Prevention, Beijing (B.W., Z.L., S.J., F.Z., Y.Q., Y.W., L.X., Y.L., X.H., C.W., Z.Z., Y.Q., X.Z., W.Z., X.H., H.S., J.C., Z.C., Y.L., X.S.).
  • Wei Y; China CDC Key Laboratory of Environment and Population Health, National Institute of Environmental Health, Chinese Center for Disease Control and Prevention, Beijing (B.W., Z.L., S.J., F.Z., Y.Q., Y.W., L.X., Y.L., X.H., C.W., Z.Z., Y.Q., X.Z., W.Z., X.H., H.S., J.C., Z.C., Y.L., X.S.).
  • Xie L; China CDC Key Laboratory of Environment and Population Health, National Institute of Environmental Health, Chinese Center for Disease Control and Prevention, Beijing (B.W., Z.L., S.J., F.Z., Y.Q., Y.W., L.X., Y.L., X.H., C.W., Z.Z., Y.Q., X.Z., W.Z., X.H., H.S., J.C., Z.C., Y.L., X.S.).
  • Li Y; China CDC Key Laboratory of Environment and Population Health, National Institute of Environmental Health, Chinese Center for Disease Control and Prevention, Beijing (B.W., Z.L., S.J., F.Z., Y.Q., Y.W., L.X., Y.L., X.H., C.W., Z.Z., Y.Q., X.Z., W.Z., X.H., H.S., J.C., Z.C., Y.L., X.S.).
  • Hu X; China CDC Key Laboratory of Environment and Population Health, National Institute of Environmental Health, Chinese Center for Disease Control and Prevention, Beijing (B.W., Z.L., S.J., F.Z., Y.Q., Y.W., L.X., Y.L., X.H., C.W., Z.Z., Y.Q., X.Z., W.Z., X.H., H.S., J.C., Z.C., Y.L., X.S.).
  • Wu C; China CDC Key Laboratory of Environment and Population Health, National Institute of Environmental Health, Chinese Center for Disease Control and Prevention, Beijing (B.W., Z.L., S.J., F.Z., Y.Q., Y.W., L.X., Y.L., X.H., C.W., Z.Z., Y.Q., X.Z., W.Z., X.H., H.S., J.C., Z.C., Y.L., X.S.).
  • Zhang Z; China CDC Key Laboratory of Environment and Population Health, National Institute of Environmental Health, Chinese Center for Disease Control and Prevention, Beijing (B.W., Z.L., S.J., F.Z., Y.Q., Y.W., L.X., Y.L., X.H., C.W., Z.Z., Y.Q., X.Z., W.Z., X.H., H.S., J.C., Z.C., Y.L., X.S.).
  • Qiu Y; China CDC Key Laboratory of Environment and Population Health, National Institute of Environmental Health, Chinese Center for Disease Control and Prevention, Beijing (B.W., Z.L., S.J., F.Z., Y.Q., Y.W., L.X., Y.L., X.H., C.W., Z.Z., Y.Q., X.Z., W.Z., X.H., H.S., J.C., Z.C., Y.L., X.S.).
  • Zheng X; China CDC Key Laboratory of Environment and Population Health, National Institute of Environmental Health, Chinese Center for Disease Control and Prevention, Beijing (B.W., Z.L., S.J., F.Z., Y.Q., Y.W., L.X., Y.L., X.H., C.W., Z.Z., Y.Q., X.Z., W.Z., X.H., H.S., J.C., Z.C., Y.L., X.S.).
  • Zhang W; China CDC Key Laboratory of Environment and Population Health, National Institute of Environmental Health, Chinese Center for Disease Control and Prevention, Beijing (B.W., Z.L., S.J., F.Z., Y.Q., Y.W., L.X., Y.L., X.H., C.W., Z.Z., Y.Q., X.Z., W.Z., X.H., H.S., J.C., Z.C., Y.L., X.S.).
  • Hu X; China CDC Key Laboratory of Environment and Population Health, National Institute of Environmental Health, Chinese Center for Disease Control and Prevention, Beijing (B.W., Z.L., S.J., F.Z., Y.Q., Y.W., L.X., Y.L., X.H., C.W., Z.Z., Y.Q., X.Z., W.Z., X.H., H.S., J.C., Z.C., Y.L., X.S.).
  • Song H; China CDC Key Laboratory of Environment and Population Health, National Institute of Environmental Health, Chinese Center for Disease Control and Prevention, Beijing (B.W., Z.L., S.J., F.Z., Y.Q., Y.W., L.X., Y.L., X.H., C.W., Z.Z., Y.Q., X.Z., W.Z., X.H., H.S., J.C., Z.C., Y.L., X.S.).
  • Cai J; China CDC Key Laboratory of Environment and Population Health, National Institute of Environmental Health, Chinese Center for Disease Control and Prevention, Beijing (B.W., Z.L., S.J., F.Z., Y.Q., Y.W., L.X., Y.L., X.H., C.W., Z.Z., Y.Q., X.Z., W.Z., X.H., H.S., J.C., Z.C., Y.L., X.S.).
  • Cao Z; China CDC Key Laboratory of Environment and Population Health, National Institute of Environmental Health, Chinese Center for Disease Control and Prevention, Beijing (B.W., Z.L., S.J., F.Z., Y.Q., Y.W., L.X., Y.L., X.H., C.W., Z.Z., Y.Q., X.Z., W.Z., X.H., H.S., J.C., Z.C., Y.L., X.S.).
  • Ji JS; Vanke School of Public Health, Tsinghua University, Beijing, China (J.S.J.).
  • Lv Y; China CDC Key Laboratory of Environment and Population Health, National Institute of Environmental Health, Chinese Center for Disease Control and Prevention, Beijing (B.W., Z.L., S.J., F.Z., Y.Q., Y.W., L.X., Y.L., X.H., C.W., Z.Z., Y.Q., X.Z., W.Z., X.H., H.S., J.C., Z.C., Y.L., X.S.).
  • Dai J; State Environmental Protection Key Laboratory of Environmental Health Impact Assessment of Emerging Contaminants, School of Environmental Science and Engineering, Shanghai Jiao Tong University, China (N.S., J.W., Y.P., J.D.).
  • Shi X; Center for Global Health, School of Public Health, Nanjing Medical University, China (J.D., X.S.).
Hypertension ; 81(8): 1799-1810, 2024 Aug.
Article in En | MEDLINE | ID: mdl-38853753
ABSTRACT

BACKGROUND:

Perfluoroalkyl and polyfluoroalkyl substance (PFAS) has endocrine-disrupting properties and may affect blood pressure. Endogenous hormones also play a crucial role in the progression of hypertension. However, their interaction with hypertension remains to be explored.

METHODS:

This study included 10 794 adults aged ≥18 years from the China National Human Biomonitoring program. Weighted multiple logistic regression and linear regression were used to examine the associations of serum PFAS with hypertension, diastolic blood pressure, and systolic blood pressure. Joint effects of PFAS mixtures on hypertension, diastolic blood pressure, and systolic blood pressure were evaluated using quantile-based g-computation. Additive and multiplicative interactions were used to assess the role of PFAS with testosterone and estradiol on hypertension.

RESULTS:

The prevalence of hypertension in Chinese adults was 35.50%. Comparing the fourth quartile with the first quartile, odds ratio (95% CI) of hypertension were 1.53 (1.13-2.09) for perfluorononanoic acid, 1.40 (1.03-1.91) for perfluorodecanoic acid, 1.34 (1.02-1.78) for perfluoroheptane sulfonic acid, and 1.46 (1.07-1.99) for perfluorooctane sulfonic acid. Moreover, PFAS mixtures, with perfluorononanoic acid contributing the most, were positively associated with hypertension, diastolic blood pressure, and systolic blood pressure. PFAS and endogenous hormones had an antagonistic interaction in hypertension. For example, the relative excess risk ratio, attributable proportion, and synergy index for perfluorononanoic acid and estradiol were -3.61 (-4.68 to -2.53), -1.65 (-2.59 to -0.71), and 0.25 (0.13-0.47), respectively.

CONCLUSIONS:

Perfluorononanoic acid, perfluorodecanoic acid, perfluoroheptane sulfonic acid, perfluorooctane sulfonic acid, and PFAS mixtures showed positive associations with hypertension, systolic blood pressure, and diastolic blood pressure. Positive associations of PFAS with hypertension might be attenuated by increased levels of endogenous sex hormones.
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Alkanesulfonic Acids / Fluorocarbons / Hypertension Limits: Adult / Female / Humans / Male / Middle aged Country/Region as subject: Asia Language: En Journal: Hypertension Year: 2024 Document type: Article Country of publication: United States
Fulltext
Add to My VHL
Print
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Alkanesulfonic Acids / Fluorocarbons / Hypertension Limits: Adult / Female / Humans / Male / Middle aged Country/Region as subject: Asia Language: En Journal: Hypertension Year: 2024 Document type: Article Country of publication: United States