Artificial Intelligence Learns Protein Prediction.
Cold Spring Harb Perspect Biol
; 16(9)2024 Sep 03.
Article
in En
| MEDLINE
| ID: mdl-38858069
ABSTRACT
From AlphaGO over StableDiffusion to ChatGPT, the recent decade of exponential advances in artificial intelligence (AI) has been altering life. In parallel, advances in computational biology are beginning to decode the language of life AlphaFold2 leaped forward in protein structure prediction, and protein language models (pLMs) replaced expertise and evolutionary information from multiple sequence alignments with information learned from reoccurring patterns in databases of billions of proteins without experimental annotations other than the amino acid sequences. None of those tools could have been developed 10 years ago; all will increase the wealth of experimental data and speed up the cycle from idea to proof. AI is affecting molecular and medical biology at giant steps, and the most important might be the leap toward more powerful protein design.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Artificial Intelligence
/
Proteins
/
Computational Biology
Language:
En
Journal:
Cold Spring Harb Perspect Biol
Journal subject:
BIOLOGIA
Year:
2024
Document type:
Article
Affiliation country:
Germany
Country of publication:
United States