Optical fiber sensing probe for detecting a carcinoembryonic antigen using a composite sensitive film of PAN nanofiber membrane and gold nanomembrane.
Opt Express
; 32(11): 20024-20034, 2024 May 20.
Article
in En
| MEDLINE
| ID: mdl-38859121
ABSTRACT
An optical fiber sensing probe using a composite sensitive film of polyacrylonitrile (PAN) nanofiber membrane and gold nanomembrane is presented for the detection of a carcinoembryonic antigen (CEA), a biomarker associated with colorectal cancer and other diseases. The probe is based on a tilted fiber Bragg grating (TFBG) with a surface plasmon resonance (SPR) gold nanomembrane and a functionalized polyacrylonitrile (PAN) PAN nanofiber coating that selectively binds to CEA molecules. The performance of the probe is evaluated by measuring the spectral shift of the TFBG resonances as a function of CEA concentration in buffer. The probe exhibits a sensitivity of 0.46â
dB/(µg/ml), a low limit of detection of 505.4â
ng/mL in buffer, and a good selectivity and reproducibility. The proposed probe offers a simple, cost-effective, and a novel method for CEA detection that can be potentially applied for clinical diagnosis and monitoring of CEA-related diseases.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Acrylic Resins
/
Carcinoembryonic Antigen
/
Surface Plasmon Resonance
/
Optical Fibers
/
Nanofibers
/
Gold
Limits:
Humans
Language:
En
Journal:
Opt Express
Journal subject:
OFTALMOLOGIA
Year:
2024
Document type:
Article