Clinicopathological Impact of FOXM1 and MMP-9 Immunohistochemical Expression in Different Grades of Intracranial Meningioma.
Appl Immunohistochem Mol Morphol
; 32(6): 292-304, 2024 Jul 01.
Article
in En
| MEDLINE
| ID: mdl-38863278
ABSTRACT
OBJECTIVES:
To find predictive biomarkers for recurrence and progression of meningioma.BACKGROUND:
Despite great advances in meningioma treatment, the prognosis remained unfavorable due to the high recurrence rate.METHODS:
In this study, we evaluated the immunohistochemical expression of FOXM1, MMP-9, and Ki67 in 50 cases of intracranial meningioma to detect its potential role in meningioma progression, recurrence, and patients' survival.RESULTS:
Strong FOXM1 expression was detected in 20% of the cases and was significantly associated with meningioma grade ( P = 0.002) and peritumoral brain edema (PTBE; P <0.001). Strong MMP-9 expression was noted in 32% of the cases and was significantly associated with meningioma grade and PTBE ( P <0.001, P <0.001, respectively). High Ki67 was noted in 50% and significantly associated with tumor grade and PTBE ( P <0.001, P = 0.002, respectively). The follow-up period revealed that meningiomas with strong FOXM1, strong MMP-9, and high Ki67 expression were associated with tumor recurrence, shorter OS, and recurrence-free survival. Furthermore, up-regulation of FOXM1 and MMP-9 expression had a significant relation with poor clinical response to the therapy ( P = 0.010, P = 0. 001, respectively). However, high Ki67 cases were more sensitive to clinical therapy ( P = 0.005).CONCLUSION:
Strong FOXM1, strong MMP-9, and high Ki67 in meningiomas indicate highly aggressive tumors with a shortened survival rate, dismal outcome, and high risk of recurrence after the standard protocol of therapy.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Immunohistochemistry
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Matrix Metalloproteinase 9
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Forkhead Box Protein M1
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Meningioma
Limits:
Adult
/
Aged
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Female
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Humans
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Male
/
Middle aged
Language:
En
Journal:
Appl Immunohistochem Mol Morphol
Journal subject:
BIOLOGIA MOLECULAR
/
HISTOCITOQUIMICA
Year:
2024
Document type:
Article
Country of publication:
United States