Ongoing pregnancy rates in single euploid frozen embryo transfers remain unaffected by female age: a retrospective study.
Reprod Biomed Online
; 49(2): 104074, 2024 Aug.
Article
in En
| MEDLINE
| ID: mdl-38865782
ABSTRACT
RESEARCH QUESTION Is female age a significant factor in the likelihood of an ongoing pregnancy in single euploid frozen embryo transfers (FET)? DESIGN:
Retrospective study of 1923 single euploid FET cycles in 1464 women, either in a natural cycle or a hormone replacement therapy cycle. The primary outcome was the ongoing pregnancy rate (OPR).RESULTS:
There were 990 (51.48%) ongoing pregnancies among 1923 included transfers. The OPR were 51.4%, 49.1%, 53.3% and 52.3% for women aged ≤35, >35-≤37, >37-≤40 and >40 years at oocyte retrieval (OCR), without a significant trend for decreasing OPR (Pâ¯=â¯0.679). No significant differences in female age at embryo transfer (Pâ¯=â¯0.609) and female age at OCR (Pâ¯=â¯0.816) were found between the groups (ongoing pregnancy versus no pregnancy or miscarriage). Women who received good-quality embryos (P < 0.001), had a lower body mass index (BMI) (P < 0.001), had achieved at least one pregnancy previously (P < 0.001), and underwent natural cycle endometrial preparation (P < 0.001) were more likely to achieve an ongoing pregnancy. Multivariable regression analysis (adjusted for BMI, embryo quality and endometrial preparation) did not show a significant effect of female age at OCR on achieving an ongoing pregnancy. Compared with women aged ≤35 years, none of the age groups had significantly higher or lower OPR. A multinomial regression analysis showed that BMI, embryo quality and endometrial preparation were associated with miscarriage/no pregnancy versus ongoing pregnancy (Pâ¯=â¯0.001, 0.001 and 0.001, respectively). Female age had no significant association with either outcome.CONCLUSIONS:
Female age in itself does not have a substantial impact on the OPR in single euploid FET cycles, but the OPR is impacted significantly by embryo quality, BMI, previous parity, and a natural cycle endometrial preparation protocol.Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Cryopreservation
/
Pregnancy Rate
Limits:
Adult
/
Female
/
Humans
/
Pregnancy
Language:
En
Journal:
Reprod Biomed Online
Journal subject:
MEDICINA REPRODUTIVA
Year:
2024
Document type:
Article