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Xanthone Inhibitors of Unfolded Protein Response Isolated from Calophyllum caledonicum.
Chambaud, Marine; Le Ray, Anne-Marie; Hamzi, Racha; Charpentier, Thomas; Blon, Nadège; Bréard, Dimitri; Le Pogam, Pierre; Litaudon, Marc; Dumontet, Vincent; Bataillé-Simoneau, Nelly; Guillemette, Thomas; Simoneau, Philippe; Schinkovitz, Andreas; Guilet, David; Viault, Guillaume; Richomme, Pascal.
Affiliation
  • Chambaud M; SONAS | Substances d'Origine Naturelle et Analogues Structuraux Univ Angers, SONAS, SFR QUASAV, F-49000 Angers, France.
  • Le Ray AM; SONAS | Substances d'Origine Naturelle et Analogues Structuraux Univ Angers, SONAS, SFR QUASAV, F-49000 Angers, France.
  • Hamzi R; SONAS | Substances d'Origine Naturelle et Analogues Structuraux Univ Angers, SONAS, SFR QUASAV, F-49000 Angers, France.
  • Charpentier T; SONAS | Substances d'Origine Naturelle et Analogues Structuraux Univ Angers, SONAS, SFR QUASAV, F-49000 Angers, France.
  • Blon N; SONAS | Substances d'Origine Naturelle et Analogues Structuraux Univ Angers, SONAS, SFR QUASAV, F-49000 Angers, France.
  • Bréard D; SONAS | Substances d'Origine Naturelle et Analogues Structuraux Univ Angers, SONAS, SFR QUASAV, F-49000 Angers, France.
  • Le Pogam P; BioCIS | Biomolécules: conception, isolement, synthèse, CNRS, UMR 8076, Université Paris-Saclay, 91400 Orsay, France.
  • Litaudon M; ICSN |Institut de Chimie des Substances Naturelles, CNRS-ICSN, UPR 2301, Université Paris-Saclay, 91198 Gif-sur-Yvette, France.
  • Dumontet V; ICSN |Institut de Chimie des Substances Naturelles, CNRS-ICSN, UPR 2301, Université Paris-Saclay, 91198 Gif-sur-Yvette, France.
  • Bataillé-Simoneau N; IRHS | Institut de Recherche en Horticulture et Semences Univ Angers, Institut Agro, INRAE, IRHS, SFR QUASAV, F-49000 Angers, France.
  • Guillemette T; IRHS | Institut de Recherche en Horticulture et Semences Univ Angers, Institut Agro, INRAE, IRHS, SFR QUASAV, F-49000 Angers, France.
  • Simoneau P; IRHS | Institut de Recherche en Horticulture et Semences Univ Angers, Institut Agro, INRAE, IRHS, SFR QUASAV, F-49000 Angers, France.
  • Schinkovitz A; SONAS | Substances d'Origine Naturelle et Analogues Structuraux Univ Angers, SONAS, SFR QUASAV, F-49000 Angers, France.
  • Guilet D; SONAS | Substances d'Origine Naturelle et Analogues Structuraux Univ Angers, SONAS, SFR QUASAV, F-49000 Angers, France.
  • Viault G; SONAS | Substances d'Origine Naturelle et Analogues Structuraux Univ Angers, SONAS, SFR QUASAV, F-49000 Angers, France.
  • Richomme P; SONAS | Substances d'Origine Naturelle et Analogues Structuraux Univ Angers, SONAS, SFR QUASAV, F-49000 Angers, France.
J Nat Prod ; 87(6): 1628-1634, 2024 Jun 28.
Article in En | MEDLINE | ID: mdl-38869194
ABSTRACT
The unfolded protein response (UPR) is a key component of fungal virulence. The prenylated xanthone γ-mangostin isolated from Garcinia mangostana (Clusiaceae) fruit pericarp, has recently been described to inhibit this fungal adaptative pathway. Considering that Calophyllum caledonicum (Calophyllaceae) is known for its high prenylated xanthone content, its stem bark extract was fractionated using a bioassay-guided procedure based on the cell-based anti-UPR assay. Four previously undescribed xanthone derivatives were isolated, caledonixanthones N-Q (3, 4, 8, and 12), among which compounds 3 and 8 showed promising anti-UPR activities with IC50 values of 11.7 ± 0.9 and 7.9 ± 0.3 µM, respectively.
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Calophyllum / Xanthones / Unfolded Protein Response Limits: Humans Language: En Journal: J Nat Prod Year: 2024 Document type: Article Affiliation country: France
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Calophyllum / Xanthones / Unfolded Protein Response Limits: Humans Language: En Journal: J Nat Prod Year: 2024 Document type: Article Affiliation country: France