Implantable photonic neural probes with out-of-plane focusing grating emitters.
Sci Rep
; 14(1): 13812, 2024 06 15.
Article
in En
| MEDLINE
| ID: mdl-38877050
ABSTRACT
We have designed, fabricated, and characterized implantable silicon neural probes with nanophotonic grating emitters that focus the emitted light at a specified distance above the surface of the probe for spatially precise optogenetic targeting of neurons. Using the holographic principle, we designed gratings for wavelengths of 488 and 594 nm, targeting the excitation spectra of the optogenetic actuators Channelrhodopsin-2 and Chrimson, respectively. The measured optical emission pattern of these emitters in non-scattering medium and tissue matched well with simulations. To our knowledge, this is the first report of focused spots with the size scale of a neuron soma in brain tissue formed from implantable neural probes.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Photons
/
Optogenetics
/
Neurons
Limits:
Animals
Language:
En
Journal:
Sci Rep
Year:
2024
Document type:
Article
Affiliation country:
Germany