Megastigmane glycosides from the traditional Uighur medicine Cydonia oblonga Mill.
Phytochemistry
; 225: 114188, 2024 Sep.
Article
in En
| MEDLINE
| ID: mdl-38878943
ABSTRACT
Phytochemical investigation on the fruits of Cydonia oblonga Mill., a traditional Uighur medicine, led to the isolation of seven undescribed and nine known megastigmane glycosides. Their structures including absolute configurations were characterized by an extensive analysis of spectroscopic data including HRESIMS and NMR, combined with ECD calculations. Additionally, compounds 1, 2, 4, and 6-16 exhibited anti-inflammatory activity by inhibiting the secretion of cytokines TNF-α and IL-6 in RAW264.7 cells induced by lipopolysaccharides (LPS) with inhibitory rates of 10.79%-44.58% at 20 µM.
Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Lipopolysaccharides
/
Cyclohexanones
/
Norisoprenoids
/
Glycosides
Limits:
Animals
Language:
En
Journal:
Phytochemistry
Year:
2024
Document type:
Article
Country of publication:
United kingdom