Sensory nerve regulation of bone homeostasis: Emerging therapeutic opportunities for bone-related diseases.
Ageing Res Rev
; 99: 102372, 2024 Aug.
Article
in En
| MEDLINE
| ID: mdl-38880342
ABSTRACT
Understanding the intricate interplay between sensory nerves and bone tissue cells is of paramount significance in the field of bone biology and clinical medicine. The regulatory role of sensory nerves in bone homeostasis offers a novel perspective for the development of targeted therapeutic interventions for a spectrum of bone-related diseases, including osteoarthritis, osteoporosis, and intervertebral disc degeneration. By elucidating the mechanisms through which sensory nerves and their neuropeptides influence the differentiation and function of bone tissue cells, this review aims to shed light on emerging therapeutic targets that harness the neuro-skeletal axis for the treatment and management of debilitating bone disorders. Moreover, a comprehensive understanding of sensory nerve-mediated bone regulation may pave the way for the development of innovative strategies to promote bone health and mitigate the burden of skeletal pathologies in clinical practice.
Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Sensory Receptor Cells
/
Bone and Bones
/
Bone Diseases
/
Homeostasis
Limits:
Animals
/
Humans
Language:
En
Journal:
Ageing Res Rev
Journal subject:
GERIATRIA
Year:
2024
Document type:
Article
Country of publication:
United kingdom