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Combination Chemotherapy Optimization with Discrete Dosing.
Ajayi, Temitayo; Hosseinian, Seyedmohammadhossein; Schaefer, Andrew J; Fuller, Clifton D.
Affiliation
  • Ajayi T; Nature Source Improved Plants, Ithaca, New York 14850.
  • Hosseinian S; Department of Mechanical and Materials Engineering, University of Cincinnati, Cincinnati, Ohio 45221.
  • Schaefer AJ; Department of Computational Applied Mathematics and Operations Research, Rice University, Houston, Texas 77005.
  • Fuller CD; Department of Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas 77030.
INFORMS J Comput ; 36(2): 434-455, 2024.
Article in En | MEDLINE | ID: mdl-38883557
ABSTRACT
Chemotherapy drug administration is a complex problem that often requires expensive clinical trials to evaluate potential regimens; one way to alleviate this burden and better inform future trials is to build reliable models for drug administration. This paper presents a mixed-integer program for combination chemotherapy (utilization of multiple drugs) optimization that incorporates various important operational constraints and, besides dose and concentration limits, controls treatment toxicity based on its effect on the count of white blood cells. To address the uncertainty of tumor heterogeneity, we also propose chance constraints that guarantee reaching an operable tumor size with a high probability in a neoadjuvant setting. We present analytical results pertinent to the accuracy of the model in representing biological processes of chemotherapy and establish its potential for clinical applications through a numerical study of breast cancer.
Key words

Full text: 1 Collection: 01-internacional Database: MEDLINE Language: En Journal: INFORMS J Comput Year: 2024 Document type: Article Country of publication: United States

Full text: 1 Collection: 01-internacional Database: MEDLINE Language: En Journal: INFORMS J Comput Year: 2024 Document type: Article Country of publication: United States