adhesiomeR: a tool for Escherichia coli adhesin classification and analysis.
BMC Genomics
; 25(1): 609, 2024 Jun 17.
Article
in En
| MEDLINE
| ID: mdl-38886681
ABSTRACT
Adhesins are crucial factors in the virulence of bacterial pathogens such as Escherichia coli. However, to date no resources have been dedicated to the detailed analysis of E. coli adhesins. Here, we provide adhesiomeR software that enables characterization of the complete adhesin repertoire, termed the adhesiome. AdhesiomeR incorporates the most comprehensive database of E. coli adhesins and facilitates an extensive analysis of adhesiome. We demonstrate that adhesiomeR achieves 98% accuracy when compared with experimental analyses. Based on analysis of 15,000 E. coli genomes, we define novel adhesiome profiles and clusters, providing a nomenclature for a unified comparison of E. coli adhesiomes.
Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Software
/
Adhesins, Escherichia coli
/
Escherichia coli
Language:
En
Journal:
BMC Genomics
Journal subject:
GENETICA
Year:
2024
Document type:
Article
Affiliation country:
United kingdom