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Clinical practice and outcome of patients with elderly-onset ulcerative colitis: Insights from a nationwide claims database study in Japan.
Moroi, Rintaro; Kakuta, Yoichi; Nagai, Hiroshi; Shimoyama, Yusuke; Naito, Takeo; Shiga, Hisashi; Kinouchi, Yoshitaka; Masamune, Atsushi.
Affiliation
  • Moroi R; Division of Gastroenterology Tohoku University Graduate School of Medicine Sendai Japan.
  • Kakuta Y; Division of Gastroenterology Tohoku University Graduate School of Medicine Sendai Japan.
  • Nagai H; Division of Gastroenterology Tohoku University Graduate School of Medicine Sendai Japan.
  • Shimoyama Y; Division of Gastroenterology Tohoku University Graduate School of Medicine Sendai Japan.
  • Naito T; Division of Gastroenterology Tohoku University Graduate School of Medicine Sendai Japan.
  • Shiga H; Division of Gastroenterology Tohoku University Graduate School of Medicine Sendai Japan.
  • Kinouchi Y; Student Healthcare Center, Institute for Excellence in Higher Education Tohoku University Sendai Japan.
  • Masamune A; Division of Gastroenterology Tohoku University Graduate School of Medicine Sendai Japan.
JGH Open ; 8(6): e13103, 2024 Jun.
Article in En | MEDLINE | ID: mdl-38887512
ABSTRACT
Background and

Aim:

The number of older patients with ulcerative colitis is increasing; however, limited data exist regarding the differences between elderly- and non-elderly-onset ulcerative colitis. We aimed to compare the clinical practice and course of elderly-onset ulcerative colitis with those of non-elderly-onset ulcerative colitis.

Methods:

We selected older patients with ulcerative colitis and divided them into the elderly- and non-elderly-onset ulcerative colitis groups according to their age at onset. We compared the cumulative systemic steroid-free, molecular targeting drug-free, and surgery-free rates between the two groups. We performed a multivariate analysis to identify the clinical factors related to systemic steroid administration, the use of molecular targeting drugs, surgery, and death.

Results:

We collected data of 2669 and 277 elderly and non-elderly-onset ulcerative colitis patients, respectively. The cumulative systemic steroid-free rate of elderly-onset ulcerative colitis was significantly lower than that of non-elderly-onset ulcerative colitis. However, no difference was observed in the cumulative molecular targeting drugs and surgery-free rates between the two groups. Elderly-onset ulcerative colitis significantly increased the risk of systemic steroid administration and death but not the use of molecular targeting drugs and surgery.

Conclusion:

The disease severity of ulcerative colitis and clinical practice may not differ between the elderly- and non-elderly-onset groups. However, elderly-onset ulcerative colitis was associated with increased mortality risk. Thus, we need to pay attention to the patients' condition and appropriate timing of surgery for patients with elderly-onset ulcerative colitis.
Key words

Full text: 1 Collection: 01-internacional Database: MEDLINE Language: En Journal: JGH Open Year: 2024 Document type: Article Country of publication: Australia

Full text: 1 Collection: 01-internacional Database: MEDLINE Language: En Journal: JGH Open Year: 2024 Document type: Article Country of publication: Australia