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Peptidome profiling of human, bovine, and donkey colostrum through label-free quantitative analysis reveals proteolysis of milk proteins.
Ning, Jianting; Chen, Jialu; Zhu, Qing; Shi, Mingyue; Chen, Jiali; Liu, Xiaoyu; Luo, Xue; Yue, Xiqing.
Affiliation
  • Ning J; College of Food Science, Shenyang Agricultural University, Shenyang 110866, China. luoxue@syau.edu.cn.
  • Chen J; College of Food Science, Shenyang Agricultural University, Shenyang 110866, China. luoxue@syau.edu.cn.
  • Zhu Q; College of Food Science, Shenyang Agricultural University, Shenyang 110866, China. luoxue@syau.edu.cn.
  • Shi M; College of Food Science, Shenyang Agricultural University, Shenyang 110866, China. luoxue@syau.edu.cn.
  • Chen J; College of Food Science, Shenyang Agricultural University, Shenyang 110866, China. luoxue@syau.edu.cn.
  • Liu X; Department of Obstetrics and Gynaecology, General Hospital of Northern Theater Command, Shenyang 110016, China.
  • Luo X; College of Food Science, Shenyang Agricultural University, Shenyang 110866, China. luoxue@syau.edu.cn.
  • Yue X; College of Food Science, Shenyang Agricultural University, Shenyang 110866, China. luoxue@syau.edu.cn.
Food Funct ; 15(13): 7161-7173, 2024 Jul 01.
Article in En | MEDLINE | ID: mdl-38888609
ABSTRACT
Proteins and peptides play vital roles in different biological processes in vivo. As a dynamic hydrolysis system, milk is rich in proteins and proteases and provides a constant supply of endogenous bioactive peptides to newborn mammals. Previous studies have primarily focused on researching bioactive peptides by adding exogenous enzymes to milk samples. However, such an approach overlooks the significance of endogenous peptides and parent proteins that naturally exist in milk. Herein, we analyzed and compared parent proteins and their releasing peptides in human colostrum (HC), bovine colostrum (BC), and donkey colostrum (DC). The predominant proteins and hydrolyzed peptides in the three types of milk were identified. Among them, peptides were found to possess common bioactivities, including ACE inhibitory, antioxidant, antibacterial and immunomodulatory properties in HC, BC, and DC. Furthermore, the biological functions of these parent proteins were clarified using bioinformatics. These insights offer a novel perspective on natural bioactive peptides and the potential utilization of specific parent proteins and peptides to develop infant formulae derived from diverse milk sources.
Subject(s)

Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Peptides / Colostrum / Equidae / Proteolysis / Milk Proteins Limits: Animals / Female / Humans Language: En Journal: Food Funct Year: 2024 Document type: Article Affiliation country: China

Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Peptides / Colostrum / Equidae / Proteolysis / Milk Proteins Limits: Animals / Female / Humans Language: En Journal: Food Funct Year: 2024 Document type: Article Affiliation country: China