Avatrombopag plus fostamatinib combination as treatment in patients with multirefractory immune thrombocytopenia.
Br J Haematol
; 2024 Jun 19.
Article
in En
| MEDLINE
| ID: mdl-38895923
ABSTRACT
Immune thrombocytopenia (ITP) refractory to multiple therapies may require a combination of drugs targeting different mechanisms and targets. In this retrospective, multicentre, international study, we report the safety and effectiveness of avatrombopag and fostamatininb in combination administered to 18 patients with multirefractory ITP. Overall, the combination response was achieved in 15 patients (83.3%), with a median time from combination start to best response of 15 days (IQR 8-35 days). After a median follow-up of 256 days (IQR 142.8-319), 5 patients relapsed (26.7%), all during tapering or stopping one drug. Adverse events were described in 6 of 18 patients (33%).
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Language:
En
Journal:
Br J Haematol
Year:
2024
Document type:
Article
Affiliation country:
Spain