Inactivation of yellow fever virus by WHO-recommended hand rub formulations and surface disinfectants.
PLoS Negl Trop Dis
; 18(6): e0012264, 2024 Jun.
Article
in En
| MEDLINE
| ID: mdl-38900788
ABSTRACT
Despite continued outbreaks of yellow fever virus (YFV) in endemic regions, data on its environmental stability or guidelines for its effective inactivation is limited. Here, we evaluated the susceptibility of the YFV 17D vaccine strain to inactivation by ethanol, 2-propanol, World Health Organization (WHO)-recommended hand rub formulations I and II, as well as surface disinfectants. In addition, two pathogenic strains were tested to compare inactivation kinetics by WHO-recommended hand rub formulations I and II. Furthermore, environmental stability of the vaccine strain was assessed. YFV 17D particles displayed infectivity half-life decay profiles of ~13 days at room temperature. Despite this extended environmental stability, YFV was efficiently inactivated by alcohols, WHO-recommended hand formulations, and four out of five tested surface disinfectants. These results are useful in defining disinfection protocols to prevent non-vector borne YFV transmission.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
World Health Organization
/
Yellow fever virus
/
Virus Inactivation
/
Disinfectants
Limits:
Animals
/
Humans
Language:
En
Journal:
PLoS Negl Trop Dis
/
PloS neglected tropical diseases
/
Plos negl. trop. dis
Journal subject:
MEDICINA TROPICAL
Year:
2024
Document type:
Article
Affiliation country:
Germany
Country of publication:
United States