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A biomimetic spore nanoplatform for boosting chemodynamic therapy and bacteria-mediated antitumor immunity for synergistic cancer treatment.
Zheng, Cuixia; Sun, Lingling; Zhao, Hongjuan; Niu, Mengya; Zhang, Dandan; Liu, Xinxin; Song, Qingling; Zhong, Weijie; Wang, Baojin; Zhang, Yun; Wang, Lei.
Affiliation
  • Zheng C; Huaihe Hospital of Henan University, Translational medicine Center, Kaifeng 475000, China.
  • Sun L; Weihai Municipal Hospital, Cheeloo College of Medicine, Shandong University, Weihai 264200, China.
  • Zhao H; School of Pharmaceutical Sciences, Zhengzhou University, Zhengzhou 450001, China.
  • Niu M; Pingyuan Lab, Henan Normal University, Xinxiang 453007, China.
  • Zhang D; School of Pharmaceutical Sciences, Zhengzhou University, Zhengzhou 450001, China.
  • Liu X; School of Pharmaceutical Sciences, Zhengzhou University, Zhengzhou 450001, China.
  • Song Q; School of Pharmaceutical Sciences, Zhengzhou University, Zhengzhou 450001, China.
  • Zhong W; School of Pharmaceutical Sciences, Zhengzhou University, Zhengzhou 450001, China.
  • Wang B; Huaihe Hospital of Henan University, Translational medicine Center, Kaifeng 475000, China.
  • Zhang Y; Gynecology, the Third Affiliated Hospital of Zhengzhou University, Zhengzhou 450052, China.
  • Wang L; School of Pharmaceutical Sciences, Zhengzhou University, Zhengzhou 450001, China.
Asian J Pharm Sci ; 19(3): 100912, 2024 Jun.
Article in En | MEDLINE | ID: mdl-38903128
ABSTRACT
Bacterial-based antitumor immunity has become a promising strategy to activate the immune system for fighting cancer. However, the potential application of bacterial therapy is hindered by the presence of instability and susceptibility to infections within bacterial populations. Furthermore, monotherapy is ineffective in completely eliminating complex cancer with multiple contributing factors. In this study, based on our discovery that spore shell (SS) of Bacillus coagulans exhibits excellent tumor-targeting ability and adjuvant activity, we develop a biomimetic spore nanoplatform to boost bacteria-mediated antitumor therapy, chemodynamic therapy and antitumor immunity for synergistic cancer treatment. In detail, SS is separated from probiotic spores and then attached to the surface of liposome (Lipo) that was loaded with hemoglobin (Hb), glucose oxidase (GOx) and JQ1 to construct SS@Lipo/Hb/GOx/JQ1. In tumor tissue, highly toxic hydroxyl radicals (•OH) are generated via sequential catalytic reactions GOx catalyzing glucose into H2O2 and Fe2+ in Hb decomposing H2O2 into •OH. The combination of •OH and SS adjuvant can improve tumor immunogenicity and activate immune system. Meanwhile, JQ1-mediated down-regulation of PD-L1 and Hb-induced hypoxia alleviation synergistically reshape immunosuppressive tumor microenvironment and potentiate immune response. In this manner, SS@Lipo/Hb/GOx/JQ1 significantly suppresses tumor growth and metastasis. To summarize, the nanoplatform represents an optimum strategy to potentiate bacteria-based cancer immunotherapy.
Key words

Full text: 1 Collection: 01-internacional Database: MEDLINE Language: En Journal: Asian J Pharm Sci Year: 2024 Document type: Article Affiliation country: China Country of publication: Netherlands

Full text: 1 Collection: 01-internacional Database: MEDLINE Language: En Journal: Asian J Pharm Sci Year: 2024 Document type: Article Affiliation country: China Country of publication: Netherlands