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Risk-reducing salpingectomy with delayed oophorectomy to prevent ovarian cancer in women with an increased inherited risk: insights into an alternative strategy.
Gootzen, T A; Steenbeek, M P; van Bommel, Mhd; IntHout, J; Kets, C M; Hermens, Rpmg; de Hullu, J A.
Affiliation
  • Gootzen TA; Department of Gynaecology and Obstetrics, Radboudumc, Geert Grooteplein Zuid 10, Nijmegen, GA, 6525, The Netherlands. tamar.gootzen@radboudumc.nl.
  • Steenbeek MP; Department of Gynaecology and Obstetrics, Radboudumc, Geert Grooteplein Zuid 10, Nijmegen, GA, 6525, The Netherlands.
  • van Bommel M; Department of Gynaecology and Obstetrics, Radboudumc, Geert Grooteplein Zuid 10, Nijmegen, GA, 6525, The Netherlands.
  • IntHout J; Department of IQ Health, Radboudumc, Kapittelweg 54, Nijmegen, EP, 6525, The Netherlands.
  • Kets CM; Department of Genetics, Radboudumc, Geert Grooteplein Zuid 10, Nijmegen, GA, 6525, The Netherlands.
  • Hermens R; Department of IQ Health, Radboudumc, Kapittelweg 54, Nijmegen, EP, 6525, The Netherlands.
  • de Hullu JA; Department of Gynaecology and Obstetrics, Radboudumc, Geert Grooteplein Zuid 10, Nijmegen, GA, 6525, The Netherlands.
Fam Cancer ; 23(4): 437-445, 2024 Nov.
Article in En | MEDLINE | ID: mdl-38907139
ABSTRACT
Epithelial ovarian cancer (EOC) is the most lethal type of gynaecological cancer, due to lack of effective screening possibilities and because the disease tends to metastasize before onset of symptoms. Women with an increased inherited risk for EOC are advised to undergo a risk-reducing salpingo-oophorectomy (RRSO), which decreases their EOC risk by 96% when performed within guideline ages. However, it also induces premature menopause, which has harmful consequences. There is compelling evidence that the majority of EOCs originate in the fallopian tube. Therefore, a risk-reducing salpingectomy with delayed oophorectomy (RRS with DO) has gained interest as an alternative strategy. Previous studies have shown that this alternative strategy has a positive effect on menopause-related quality of life and sexual health when compared to the standard RRSO. It is hypothesized that the alternative strategy is non-inferior to the standard RRSO with respect to oncological safety (EOC incidence). Three prospective studies are currently including patients to compare the safety and/or quality of life of the two distinct strategies. In this article we discuss the background, opportunities, and challenges of the current and alternative strategy.
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Ovarian Neoplasms / Quality of Life / Ovariectomy / Genetic Predisposition to Disease / Salpingectomy / Carcinoma, Ovarian Epithelial Limits: Female / Humans Language: En Journal: Fam Cancer Journal subject: NEOPLASIAS Year: 2024 Document type: Article Affiliation country: Netherlands Country of publication: Netherlands

Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Ovarian Neoplasms / Quality of Life / Ovariectomy / Genetic Predisposition to Disease / Salpingectomy / Carcinoma, Ovarian Epithelial Limits: Female / Humans Language: En Journal: Fam Cancer Journal subject: NEOPLASIAS Year: 2024 Document type: Article Affiliation country: Netherlands Country of publication: Netherlands