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Involvement of the cingulate cortex and insula in patients with trigeminal neuralgia: A clinical and volumetric study.
Mammadkhanli, Orkhan; Niftaliyev, Seymur; Simsek, Osman.
Affiliation
  • Mammadkhanli O; Trakya University, Department of Neurosurgery, Edirne, Turkey; Hacettepe University, Department of Anatomy, Ankara, Turkey. Electronic address: dr.mammadkhanli@gmail.com.
  • Niftaliyev S; Istanbul Okan University Hospital, Department of Neurosurgery, Istanbul, Turkey.
  • Simsek O; Trakya University, Department of Neurosurgery, Edirne, Turkey.
Clin Neurol Neurosurg ; 243: 108394, 2024 Aug.
Article in En | MEDLINE | ID: mdl-38908321
ABSTRACT

AIM:

Advanced neuroimaging strategies may provide new insights into the underlying mechanisms of trigeminal neuralgia (TN). The objective of this study is to measure central pain centers in patients with long-standing trigeminal neuralgia and compare them to those of normal individuals. The findings of this study could improve the understanding of central region changes related to pain and improve the diagnosis and management of chronic trigeminal pain. MATERIAL AND

METHODS:

We examined radiologic data from 20 patients with trigeminal neuralgia and 28 healthy controls who underwent 3D iso T1-weighted brain MRI at our university hospital between 2018 and 2023. Patients with a minimum pain duration of 5 years were included and compared with healthy controls. Additionally, patients were categorized into groups based on the presence of vascular compression. The pain-related subcortical structures, such as the cingulate cortex and insula, were analyzed volumetrically using volBrain software. The results were evaluated statistically.

RESULTS:

Significant differences were observed in the measurement of the posterior insula (p = 0.014) when comparing patients with trigeminal neuralgia and healthy subjects. Additionally, group comparisons based on the presence of vascular compression revealed significant differences in the Middle Cingulate Cortex (0.036) and Posterior Cingulate Cortex (0.031) between groups, which may be related to the etiological factor.

CONCLUSION:

Understanding changes in central regions related to pain can aid in the diagnosis and management of chronic trigeminal pain.
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Trigeminal Neuralgia / Magnetic Resonance Imaging / Gyrus Cinguli Limits: Adult / Aged / Female / Humans / Male / Middle aged Language: En Journal: Clin Neurol Neurosurg Year: 2024 Document type: Article

Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Trigeminal Neuralgia / Magnetic Resonance Imaging / Gyrus Cinguli Limits: Adult / Aged / Female / Humans / Male / Middle aged Language: En Journal: Clin Neurol Neurosurg Year: 2024 Document type: Article