Long-term Outcomes After Kidney Transplantation From DBD Donors Aged 70 y and Older.
Transplant Direct
; 10(7): e1660, 2024 Jul.
Article
in En
| MEDLINE
| ID: mdl-38911276
ABSTRACT
Background:
Transplantation of kidneys from elderly donations after brain death (DBD) donors has increased owing to organ shortages. We aimed to assess the impact on long-term kidney transplant outcomes from DBD donors aged 70 y and older compared with kidneys from younger donors.Methods:
From 2007 to 2022, 2274 first single kidney transplantations from DBD donors were performed at our center. Data from 1417 kidney transplant recipients receiving a DBD organ were included and categorized into 3 groups according to donor age 70 y and older (nâ =â 444, median age 74 y), 60-69 y (nâ =â 527, median age 64 y), and a reference group consisting of donors aged 45-54 y (nâ =â 446, median age 50 y). Kaplan-Meier plots and multivariate Cox regression with correction for recipient, donor, and transplant characteristics were used to investigate patient and kidney graft survival outcomes.Results:
The median patient follow-up time was 9.3 y (interquartile range, 5.3-13.1). The adjusted hazard ratios for patient death in recipients of kidneys from DBD donors aged 70 y and older compared with 60-69 y and 45-54 y were 1.12 (95% confidence interval [CI], 0.92-1.36; Pâ =â 0.26) and 1.62 (95% CI, 1.26-2.07; Pâ <â 0.001), respectively. Compared with recipients of donors aged 60-69 y and 45-54 y, the adjusted hazard ratios for kidney graft loss in recipients of donors aged 70 y and older were 1.23 (95% CI, 1.02-1.48; Pâ =â 0.029) and 1.94 (95% CI, 1.54-2.45; Pâ <â 0.001), respectively.Conclusions:
Transplantation of kidneys from DBD donors aged 70 y and older resulted in acceptable long-term outcomes and is encouraging.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Language:
En
Journal:
Transplant Direct
/
Transplantation direct
Year:
2024
Document type:
Article
Affiliation country:
Norway
Country of publication:
United States