Molecular determinants of cross-species transmission in emerging viral infections.
Microbiol Mol Biol Rev
; 88(3): e0000123, 2024 Sep 26.
Article
in En
| MEDLINE
| ID: mdl-38912755
ABSTRACT
SUMMARYSeveral examples of high-impact cross-species transmission of newly emerging or re-emerging bat-borne viruses, such as Sudan virus, Nipah virus, and severe acute respiratory syndrome coronavirus 2, have occurred in the past decades. Recent advancements in next-generation sequencing have strengthened ongoing efforts to catalog the global virome, in particular from the multitude of different bat species. However, functional characterization of these novel viruses and virus sequences is typically limited with regard to assessment of their cross-species potential. Our understanding of the intricate interplay between virus and host underlying successful cross-species transmission has focused on the basic mechanisms of entry and replication, as well as the importance of host innate immune responses. In this review, we discuss the various roles of the respective molecular mechanisms underlying cross-species transmission using different recent bat-borne viruses as examples. To delineate the crucial cellular and molecular steps underlying cross-species transmission, we propose a framework of overall characterization to improve our capacity to characterize viruses as benign, of interest, or of concern.
Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Chiroptera
/
Communicable Diseases, Emerging
Limits:
Animals
/
Humans
Language:
En
Journal:
Microbiol Mol Biol Rev
Journal subject:
BIOLOGIA MOLECULAR
/
MICROBIOLOGIA
Year:
2024
Document type:
Article
Affiliation country:
United States
Country of publication:
United States