Locally advanced breast cancer patients should be cautious about the immediate breast reconstruction after mastectomy: a pooling analysis of safety and efficacy.
World J Surg Oncol
; 22(1): 165, 2024 Jun 25.
Article
in En
| MEDLINE
| ID: mdl-38918808
ABSTRACT
BACKGROUND:
The purpose of this study was to compare safety and efficacy outcomes between immediate breast reconstruction (IBR) and mastectomy alone in locally advanced breast cancer patients.METHODS:
We conducted a comprehensive literature search of PUBMED, EMBASE, and Cochrane databases. The primary outcomes evaluated were overall survival, disease-free survival, and local recurrence. The secondary outcome was the incidence of surgical complications. All data were analyzed using Review Manager 5.3.RESULTS:
Sixteen studies, involving 15,364 participants were included in this meta-analysis. Pooled data demonstrated that patients underwent IBR were more likely to experience surgical complications than those underwent mastectomy alone (HR 3.96, 95%CI [1.07,14.67], p = 0.04). No significant difference was found in overall survival (HR 0.94, 95%CI [0.73,1.20], p = 0.62), disease-free survival (HR 1.03, 95%CI [0.83,1.27], p = 0.81), or breast cancer specific survival (HR 0.93, 95%CI [0.71,1.21], p = 0.57) between IBR group and Non-IBR group.CONCLUSIONS:
Our study demonstrates that IBR after mastectomy does not affect the overall survival and disease-free survival of locally advanced breast cancer patients. However, IBR brings with it a nonnegligible higher risk of complications and needs to be fully evaluated and carefully decided.Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Postoperative Complications
/
Breast Neoplasms
/
Mammaplasty
/
Mastectomy
Limits:
Female
/
Humans
Language:
En
Journal:
World J Surg Oncol
Year:
2024
Document type:
Article
Affiliation country:
China