Cocaine and amphetamine-regulated transcript improves myocardial ischemia-reperfusion injury through PI3K/AKT signalling pathway.
Clin Exp Pharmacol Physiol
; 51(8): e13904, 2024 Aug.
Article
in En
| MEDLINE
| ID: mdl-38923060
ABSTRACT
Myocardial ischemia-reperfusion injury (MIRI) is a common clinic scenario that occurs in the context of reperfusion therapy for acute myocardial infarction. It has been shown that cocaine and amphetamine-regulated transcript (CART) can ameliorate cerebral ischemia-reperfusion (I/R) injury, but the effect of CART on MIRI has not been studied yet. Here, we revealed that CART protected the heart during I/R process by inhibiting apoptosis and excessive autophagy, indicating that CART would be a potential drug candidate for the treatment of MIRI. Further analysis showed that CART upregulated the activation of phospho-AKT, leading to downregulation of lactate dehydrogenase (LDH) release, apoptosis, oxidative stress and excessive autophagy after I/R, which was inhibited by PI3K inhibitor, LY294002. Collectively, CART attenuated MIRI through inhibition of cardiomyocytes apoptosis and excessive autophagy, and the protective effect was dependent on PI3K/AKT signalling pathway.
Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Autophagy
/
Myocardial Reperfusion Injury
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Signal Transduction
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Apoptosis
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Phosphatidylinositol 3-Kinases
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Proto-Oncogene Proteins c-akt
/
Nerve Tissue Proteins
Limits:
Animals
Language:
En
Journal:
Clin Exp Pharmacol Physiol
Year:
2024
Document type:
Article
Affiliation country:
China