Hepatitis C virus and hepatocellular carcinoma: carcinogenesis in the era of direct-acting antivirals.
Curr Opin Virol
; 67: 101423, 2024 Aug.
Article
in En
| MEDLINE
| ID: mdl-38925094
ABSTRACT
Chronic hepatitis C virus (HCV) infection is a major cause of hepatic fibrosis and cirrhosis, with a risk for the development of hepatocellular carcinoma (HCC). Although highly effective direct-acting antivirals (DAAs) are available, the incidence, morbidity, and mortality of HCV-associated HCC are still high. This article reviews the current knowledge of the mechanisms of HCV-induced carcinogenesis with a special focus on those processes that continue after virus clearance and outlines implications for patient surveillance after DAA treatment.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Antiviral Agents
/
Hepacivirus
/
Carcinoma, Hepatocellular
/
Hepatitis C, Chronic
/
Carcinogenesis
/
Liver Neoplasms
Limits:
Animals
/
Humans
Language:
En
Journal:
Curr Opin Virol
Year:
2024
Document type:
Article
Affiliation country:
Germany
Country of publication:
Netherlands