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Gene-environment interactions within a precision environmental health framework.
Motsinger-Reif, Alison A; Reif, David M; Akhtari, Farida S; House, John S; Campbell, C Ryan; Messier, Kyle P; Fargo, David C; Bowen, Tiffany A; Nadadur, Srikanth S; Schmitt, Charles P; Pettibone, Kristianna G; Balshaw, David M; Lawler, Cindy P; Newton, Shelia A; Collman, Gwen W; Miller, Aubrey K; Merrick, B Alex; Cui, Yuxia; Anchang, Benedict; Harmon, Quaker E; McAllister, Kimberly A; Woychik, Rick.
Affiliation
  • Motsinger-Reif AA; Biostatistics and Computational Biology Branch, Division of Intramural Research, National Institute of Environmental Health Sciences, Durham, NC, USA. Electronic address: alison.motsinger-reif@nih.gov.
  • Reif DM; Predictive Toxicology Branch, Division of Translational Toxicology, National Institute of Environmental Health Sciences, Durham, NC, USA.
  • Akhtari FS; Biostatistics and Computational Biology Branch, Division of Intramural Research, National Institute of Environmental Health Sciences, Durham, NC, USA.
  • House JS; Biostatistics and Computational Biology Branch, Division of Intramural Research, National Institute of Environmental Health Sciences, Durham, NC, USA.
  • Campbell CR; Biostatistics and Computational Biology Branch, Division of Intramural Research, National Institute of Environmental Health Sciences, Durham, NC, USA.
  • Messier KP; Biostatistics and Computational Biology Branch, Division of Intramural Research, National Institute of Environmental Health Sciences, Durham, NC, USA; Predictive Toxicology Branch, Division of Translational Toxicology, National Institute of Environmental Health Sciences, Durham, NC, USA.
  • Fargo DC; Office of the Director, National Institute of Environmental Health Sciences, Durham, NC, USA.
  • Bowen TA; Office of the Director, National Institute of Environmental Health Sciences, Durham, NC, USA.
  • Nadadur SS; Exposure, Response, and Technology Branch, Division of Extramural Research and Training, National Institute of Environmental Health Sciences, Durham, NC, USA.
  • Schmitt CP; Office of the Scientific Director, Office of Data Science, National Institute of Environmental Health Sciences, Durham, NC, USA.
  • Pettibone KG; Program Analysis Branch, Division of Extramural Research and Training, National Institute of Environmental Health Sciences, Durham, NC, USA.
  • Balshaw DM; Office of the Director, National Institute of Environmental Health Sciences, Durham, NC, USA; Division of Extramural Research and Training, National Institute of Environmental Health Sciences, Durham, NC, USA.
  • Lawler CP; Genes, Environment, and Health Branch, Division of Extramural Research and Training, National Institute of Environmental Health Sciences, Durham, NC, USA.
  • Newton SA; Office of Scientific Coordination, Planning and Evaluation, National Institute of Environmental Health Sciences, Durham, NC, USA.
  • Collman GW; Office of the Director, National Institute of Environmental Health Sciences, Durham, NC, USA; Office of Scientific Coordination, Planning and Evaluation, National Institute of Environmental Health Sciences, Durham, NC, USA.
  • Miller AK; Office of Scientific Coordination, Planning and Evaluation, National Institute of Environmental Health Sciences, Durham, NC, USA.
  • Merrick BA; Mechanistic Toxicology Branch, Division of Translational Toxicology, National Institute of Environmental Health Sciences, Durham, NC, USA.
  • Cui Y; Exposure, Response, and Technology Branch, Division of Extramural Research and Training, National Institute of Environmental Health Sciences, Durham, NC, USA.
  • Anchang B; Biostatistics and Computational Biology Branch, Division of Intramural Research, National Institute of Environmental Health Sciences, Durham, NC, USA.
  • Harmon QE; Epidemiology Branch, Division of Intramural Research, National Institute of Environmental Health Sciences, Durham, NC, USA.
  • McAllister KA; Genes, Environment, and Health Branch, Division of Extramural Research and Training, National Institute of Environmental Health Sciences, Durham, NC, USA.
  • Woychik R; Office of the Director, National Institute of Environmental Health Sciences, Durham, NC, USA.
Cell Genom ; 4(7): 100591, 2024 Jul 10.
Article in En | MEDLINE | ID: mdl-38925123
ABSTRACT
Understanding the complex interplay of genetic and environmental factors in disease etiology and the role of gene-environment interactions (GEIs) across human development stages is important. We review the state of GEI research, including challenges in measuring environmental factors and advantages of GEI analysis in understanding disease mechanisms. We discuss the evolution of GEI studies from candidate gene-environment studies to genome-wide interaction studies (GWISs) and the role of multi-omics in mediating GEI effects. We review advancements in GEI analysis methods and the importance of large-scale datasets. We also address the translation of GEI findings into precision environmental health (PEH), showcasing real-world applications in healthcare and disease prevention. Additionally, we highlight societal considerations in GEI research, including environmental justice, the return of results to participants, and data privacy. Overall, we underscore the significance of GEI for disease prediction and prevention and advocate for integrating the exposome into PEH omics studies.
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Environmental Health / Precision Medicine / Gene-Environment Interaction Limits: Humans Language: En Journal: Cell Genom Year: 2024 Document type: Article
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Environmental Health / Precision Medicine / Gene-Environment Interaction Limits: Humans Language: En Journal: Cell Genom Year: 2024 Document type: Article