Effect of Acute Nutritional Ketosis on Circulating Levels of Growth Differentiation Factor 15: Findings from a Cross-Over Randomised Controlled Trial.
Biomolecules
; 14(6)2024 Jun 06.
Article
in En
| MEDLINE
| ID: mdl-38927068
ABSTRACT
Exogenous supplementation with ketone beverages has been shown to reduce plasma glucose levels during acute nutritional ketosis. It remains to be investigated whether growth differentiation factor 15 (GDF-15)-an anorexigenic hormone-is involved in this process. The aim was to investigate the effect of a ketone ester beverage delivering ß-hydroxybutyrate (KEßHB) on plasma levels of GDF-15, as well as assess the influence of eating behaviour on it. The study was a randomised controlled trial (registered at clinicaltrials.gov as NCT03889210). Individuals were given a KEßHB beverage or placebo in a cross-over fashion. Blood samples were collected at baseline, 30, 60, 90, 120, and 150 min after ingestion. Eating behaviour was assessed using the three-factor eating questionnaire. GDF-15 levels were not significantly different (p = 0.503) after the KEßHB beverage compared with the placebo. This finding remained consistent across the cognitive restraint, emotional eating, and uncontrolled eating domains. Changes in the anorexigenic hormone GDF-15, irrespective of eating behaviour, do not appear to play a major role in the glucose-lowering effect of exogenous ketones.
Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Cross-Over Studies
/
3-Hydroxybutyric Acid
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Growth Differentiation Factor 15
/
Ketosis
Limits:
Adult
/
Female
/
Humans
/
Male
Language:
En
Journal:
Biomolecules
Year:
2024
Document type:
Article
Affiliation country:
New Zealand