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Hair Thickness Growth Effect of Adenosine Complex in Male-/Female-Patterned Hair Loss via Inhibition of Androgen Receptor Signaling.
Kim, Jaeyoon; Shin, Jae Young; Choi, Yun-Ho; Joo, Jang Ho; Kwack, Mi Hee; Sung, Young Kwan; Kang, Nae Gyu.
Affiliation
  • Kim J; LG Household & Health Care (LG H&H) R&D Center, 70, Magokjoongang 10-ro, Gangseo-gu, Seoul 07795, Republic of Korea.
  • Shin JY; LG Household & Health Care (LG H&H) R&D Center, 70, Magokjoongang 10-ro, Gangseo-gu, Seoul 07795, Republic of Korea.
  • Choi YH; LG Household & Health Care (LG H&H) R&D Center, 70, Magokjoongang 10-ro, Gangseo-gu, Seoul 07795, Republic of Korea.
  • Joo JH; LG Household & Health Care (LG H&H) R&D Center, 70, Magokjoongang 10-ro, Gangseo-gu, Seoul 07795, Republic of Korea.
  • Kwack MH; Department of Immunology, School of Medicine, Kyungpook National University, Daegu 41944, Republic of Korea.
  • Sung YK; Department of Immunology, School of Medicine, Kyungpook National University, Daegu 41944, Republic of Korea.
  • Kang NG; LG Household & Health Care (LG H&H) R&D Center, 70, Magokjoongang 10-ro, Gangseo-gu, Seoul 07795, Republic of Korea.
Int J Mol Sci ; 25(12)2024 Jun 13.
Article in En | MEDLINE | ID: mdl-38928239
ABSTRACT
Aging (senescence) is an unavoidable biological process that results in visible manifestations in all cutaneous tissues, including scalp skin and hair follicles. Previously, we evaluated the molecular function of adenosine in promoting alopecia treatment in vitro. To elucidate the differences in the molecular mechanisms between minoxidil (MNX) and adenosine, gene expression changes in dermal papilla cells were examined. The androgen receptor (AR) pathway was identified as a candidate target of adenosine for hair growth, and the anti-androgenic activity of adenosine was examined in vitro. In addition, ex vivo examination of human hair follicle organ cultures revealed that adenosine potently elongated the anagen stage. According to the severity of alopecia, the ratio of the two peaks (terminal hair area/vellus hair area) decreased continuously. We further investigated the adenosine hair growth promoting effect in vivo to examine the hair thickness growth effects of topical 5% MNX and the adenosine complex (0.75% adenosine, 1% penthenol, and 2% niacinamide; APN) in vivo. After 4 months of administration, both the MNX and APN group showed significant increases in hair density (MNX + 5.01% (p < 0.01), APN + 6.20% (p < 0.001)) and thickness (MNX + 5.14% (p < 0.001), APN + 10.32% (p < 0.001)). The inhibition of AR signaling via adenosine could have contributed to hair thickness growth. We suggest that the anti-androgenic effect of adenosine, along with the evaluation of hair thickness distribution, could help us to understand hair physiology and to investigate new approaches for drug development.
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Signal Transduction / Receptors, Androgen / Adenosine / Hair Follicle / Alopecia / Hair / Minoxidil Limits: Animals / Female / Humans / Male Language: En Journal: Int J Mol Sci Year: 2024 Document type: Article Country of publication: Switzerland

Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Signal Transduction / Receptors, Androgen / Adenosine / Hair Follicle / Alopecia / Hair / Minoxidil Limits: Animals / Female / Humans / Male Language: En Journal: Int J Mol Sci Year: 2024 Document type: Article Country of publication: Switzerland