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Pathological Functions of Lysosomal Ion Channels in the Central Nervous System.
Cen, Jianke; Hu, Nan; Shen, Jiawen; Gao, Yongjing; Lu, Huanjun.
Affiliation
  • Cen J; Institute of Pain Medicine and Special Environmental Medicine, Co-Innovation Center of Neuroregeneration, Nantong University, Nantong 226019, China.
  • Hu N; Institute of Pain Medicine and Special Environmental Medicine, Co-Innovation Center of Neuroregeneration, Nantong University, Nantong 226019, China.
  • Shen J; Institute of Pain Medicine and Special Environmental Medicine, Co-Innovation Center of Neuroregeneration, Nantong University, Nantong 226019, China.
  • Gao Y; Institute of Pain Medicine and Special Environmental Medicine, Co-Innovation Center of Neuroregeneration, Nantong University, Nantong 226019, China.
  • Lu H; Institute of Pain Medicine and Special Environmental Medicine, Co-Innovation Center of Neuroregeneration, Nantong University, Nantong 226019, China.
Int J Mol Sci ; 25(12)2024 Jun 14.
Article in En | MEDLINE | ID: mdl-38928271
ABSTRACT
Lysosomes are highly dynamic organelles that maintain cellular homeostasis and regulate fundamental cellular processes by integrating multiple metabolic pathways. Lysosomal ion channels such as TRPML1-3, TPC1/2, ClC6/7, CLN7, and TMEM175 mediate the flux of Ca2+, Cl-, Na+, H+, and K+ across lysosomal membranes in response to osmotic stimulus, nutrient-dependent signals, and cellular stresses. These ion channels serve as the crucial transducers of cell signals and are essential for the regulation of lysosomal biogenesis, motility, membrane contact site formation, and lysosomal homeostasis. In terms of pathophysiology, genetic variations in these channel genes have been associated with the development of lysosomal storage diseases, neurodegenerative diseases, inflammation, and cancer. This review aims to discuss the current understanding of the role of these ion channels in the central nervous system and to assess their potential as drug targets.
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Central Nervous System / Ion Channels / Lysosomes Limits: Animals / Humans Language: En Journal: Int J Mol Sci Year: 2024 Document type: Article Affiliation country: China

Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Central Nervous System / Ion Channels / Lysosomes Limits: Animals / Humans Language: En Journal: Int J Mol Sci Year: 2024 Document type: Article Affiliation country: China