Biophysics of morphogenesis in the vertebrate lung.
Curr Top Dev Biol
; 160: 65-86, 2024.
Article
in En
| MEDLINE
| ID: mdl-38937031
ABSTRACT
Morphogenesis is a physical process that sculpts the final functional forms of tissues and organs. Remarkably, the lungs of terrestrial vertebrates vary dramatically in form across species, despite providing the same function of transporting oxygen and carbon dioxide. These divergent forms arise from distinct physical processes through which the epithelium of the embryonic lung responds to the mechanical properties of its surrounding mesenchymal microenvironment. Here we compare the physical processes that guide folding of the lung epithelium in mammals, birds, and reptiles, and suggest a conceptual framework that reconciles how conserved molecular signaling generates divergent mechanical forces across these species.
Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Vertebrates
/
Lung
/
Morphogenesis
Limits:
Animals
/
Humans
Language:
En
Journal:
Curr Top Dev Biol
Year:
2024
Document type:
Article
Affiliation country:
United States