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Aptamer-assisted phage display: enhancing checkpoint inhibition with a peptide and an aptamer targeting distinct sites on a single PD-L1 protein.
Arya, Satya Prakash; Thennakoon, Siddhartha Kalpa Samadhi; Phuoc, Chien Minh Tran; Silwal, Achut Prasad; Jahan, Raunak; Postema, Rick Mason; Timilsina, Hari; Reynolds, Andrew Michael; Tan, Xiaohong.
Affiliation
  • Arya SP; Department of Chemistry and Center for Photochemical Sciences, Bowling Green State University, Bowling Green, Ohio 43403, USA. tanx@bgsu.edu.
  • Thennakoon SKS; Department of Chemistry and Center for Photochemical Sciences, Bowling Green State University, Bowling Green, Ohio 43403, USA. tanx@bgsu.edu.
  • Phuoc CMT; Department of Chemistry and Center for Photochemical Sciences, Bowling Green State University, Bowling Green, Ohio 43403, USA. tanx@bgsu.edu.
  • Silwal AP; Department of Chemistry and Center for Photochemical Sciences, Bowling Green State University, Bowling Green, Ohio 43403, USA. tanx@bgsu.edu.
  • Jahan R; Department of Chemistry and Center for Photochemical Sciences, Bowling Green State University, Bowling Green, Ohio 43403, USA. tanx@bgsu.edu.
  • Postema RM; Department of Chemistry and Center for Photochemical Sciences, Bowling Green State University, Bowling Green, Ohio 43403, USA. tanx@bgsu.edu.
  • Timilsina H; Department of Chemistry and Center for Photochemical Sciences, Bowling Green State University, Bowling Green, Ohio 43403, USA. tanx@bgsu.edu.
  • Reynolds AM; Department of Chemistry and Center for Photochemical Sciences, Bowling Green State University, Bowling Green, Ohio 43403, USA. tanx@bgsu.edu.
  • Tan X; Department of Chemistry and Center for Photochemical Sciences, Bowling Green State University, Bowling Green, Ohio 43403, USA. tanx@bgsu.edu.
Chem Commun (Camb) ; 60(59): 7570-7573, 2024 Jul 18.
Article in En | MEDLINE | ID: mdl-38940673
ABSTRACT
Utilizing a novel approach known as aptamer-assisted phage display (APD), we identified an anti-PD-L1 peptide, NV Pep, capable of simultaneous binding to PD-L1 alongside the DNA aptamer MJ5C. Combined inhibition using NV Pep and MJ5C demonstrated significant enhancement compared to individual ligands against the PD-1/PD-L1 interaction.
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Peptides / Aptamers, Nucleotide / B7-H1 Antigen Limits: Humans Language: En Journal: Chem Commun (Camb) Journal subject: QUIMICA Year: 2024 Document type: Article Affiliation country: United States
Fulltext
Add to My VHL
Print
XML
PubMed Links
Search on Google

Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Peptides / Aptamers, Nucleotide / B7-H1 Antigen Limits: Humans Language: En Journal: Chem Commun (Camb) Journal subject: QUIMICA Year: 2024 Document type: Article Affiliation country: United States