Tuning the Emission of Bis-ethylenedioxythiophene-thiophenes upon Aggregation.
J Phys Chem B
; 128(27): 6581-6588, 2024 Jul 11.
Article
in En
| MEDLINE
| ID: mdl-38942741
ABSTRACT
The ability of small lipophilic molecules to penetrate the blood-brain barrier through transmembrane diffusion has enabled researchers to explore new diagnostics and therapies for brain disorders. Until now, therapies targeting the brain have mainly relied on biochemical mechanisms, while electrical treatments such as deep brain stimulation often require invasive procedures. An alternative to implanting deep brain stimulation probes could involve administering small molecule precursors intravenously, capable of crossing the blood-brain barrier, and initiating the formation of conductive polymer networks in the brain through in vivo polymerization. This study examines the aggregation behavior of five water-soluble conducting polymer precursors sharing the same conjugate core but differing in side chains, using spectroscopy and various computational chemistry tools. Our findings highlight the significant impact of side chain composition on both aggregation and spectroscopic response.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Thiophenes
Language:
En
Journal:
J Phys Chem B
Journal subject:
QUIMICA
Year:
2024
Document type:
Article
Affiliation country:
Sweden