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Pan-RAF:MEK Molecular Glues Take Center Stage.
Hangauer, Matthew J; Gutkind, Jorge Silvio; Ferguson, Fleur M.
Affiliation
  • Hangauer MJ; Department of Dermatology, University of California San Diego, La Jolla, California.
  • Gutkind JS; UCSD Moores Cancer Center, University of California San Diego, La Jolla, California.
  • Ferguson FM; Department of Pharmacology, University of California San Diego, La Jolla, California.
Cancer Discov ; 14(7): 1143-1144, 2024 Jul 01.
Article in En | MEDLINE | ID: mdl-38946324
ABSTRACT
In this issue, Ryan and colleagues describe the preclinical development of a pan-RAFMEK molecular glue with superior efficacy, brain penetrance, and tolerability in xenograft models of Ras/Raf/MAPK pathway-driven tumors. See related article by Ryan et al., p. 1190 (1).
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Protein Kinase Inhibitors Limits: Animals / Humans Language: En Journal: Cancer Discov Year: 2024 Document type: Article Country of publication: United States
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Protein Kinase Inhibitors Limits: Animals / Humans Language: En Journal: Cancer Discov Year: 2024 Document type: Article Country of publication: United States