Your browser doesn't support javascript.
loading
Plasma and CSF biomarkers of aging and cognitive decline in Caribbean vervets.
Varma, Curran; Luo, Eva; Bostrom, Gustaf; Bathini, Praveen; Berdnik, Daniela; Wyss-Coray, Tony; Zhao, Tingting; Dong, Xianjun; Ervin, Frank R; Beierschmitt, Amy; Palmour, Roberta M; Lemere, Cynthia A.
Affiliation
  • Varma C; Department of Neurology, Ann Romney Center for Neurologic Diseases, Brigham and Women's Hospital, Boston, Massachusetts, USA.
  • Luo E; Department of Neurology, Ann Romney Center for Neurologic Diseases, Brigham and Women's Hospital, Boston, Massachusetts, USA.
  • Bostrom G; Department of Neurology, Ann Romney Center for Neurologic Diseases, Brigham and Women's Hospital, Boston, Massachusetts, USA.
  • Bathini P; Department of Neurology, Harvard Medical School, Boston, Massachusetts, USA.
  • Berdnik D; Department of Public Health and Caring Sciences, Geriatrics, Uppsala University, Uppsala, Sweden.
  • Wyss-Coray T; Centre for Clinical Research, Uppsala University, Västmanland County Hospital, Västerås, Sweden.
  • Zhao T; Department of Neurology, Ann Romney Center for Neurologic Diseases, Brigham and Women's Hospital, Boston, Massachusetts, USA.
  • Dong X; Department of Neurology, Harvard Medical School, Boston, Massachusetts, USA.
  • Ervin FR; Department of Neurology and Neurological Sciences, Stanford University School of Medicine, Stanford, California, USA.
  • Beierschmitt A; Department of Neurology and Neurological Sciences, Stanford University School of Medicine, Stanford, California, USA.
  • Palmour RM; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts, USA.
  • Lemere CA; Department of Neurology, Ann Romney Center for Neurologic Diseases, Brigham and Women's Hospital, Boston, Massachusetts, USA.
Alzheimers Dement ; 20(8): 5460-5480, 2024 08.
Article in En | MEDLINE | ID: mdl-38946666
ABSTRACT

INTRODUCTION:

Vervets are non-human primates that share high genetic homology with humans and develop amyloid beta (Aß) pathology with aging. We expand current knowledge by examining Aß pathology, aging, cognition, and biomarker proteomics.

METHODS:

Amyloid immunoreactivity in the frontal cortex and temporal cortex/hippocampal regions from archived vervet brain samples ranging from young adulthood to old age was quantified. We also obtained cognitive scores, plasma samples, and cerebrospinal fluid (CSF) samples in additional animals. Plasma and CSF proteins were quantified with platforms utilizing human antibodies.

RESULTS:

We found age-related increases in Aß deposition in both brain regions. Bioinformatic analyses assessed associations between biomarkers and age, sex, cognition, and CSF Aß levels, revealing changes in proteins related to immune-related inflammation, metabolism, and cellular processes.

DISCUSSION:

Vervets are an effective model of aging and early-stage Alzheimer's disease, and we provide translational biomarker data that both align with previous results in humans and provide a basis for future investigations. HIGHLIGHTS We found changes in immune and metabolic plasma biomarkers associated with age and cognition. Cerebrospinal fluid (CSF) biomarkers revealed changes in cell signaling indicative of adaptative processes. TNFRSF19 (TROY) and Artemin co-localize with Alzheimer's disease pathology. Vervets are a relevant model for translational studies of early-stage Alzheimer's disease.
Subject(s)
Key words
Fulltext
Add to My VHL
Print
XML
PubMed Links
Search on Google

Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Aging / Biomarkers / Amyloid beta-Peptides / Cognitive Dysfunction Limits: Animals / Female / Humans / Male Language: En Journal: Alzheimers Dement Year: 2024 Document type: Article Affiliation country: United States
Fulltext
Add to My VHL
Print
XML
PubMed Links
Search on Google

Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Aging / Biomarkers / Amyloid beta-Peptides / Cognitive Dysfunction Limits: Animals / Female / Humans / Male Language: En Journal: Alzheimers Dement Year: 2024 Document type: Article Affiliation country: United States