Effects of differences in dose and frequency of teriparatide on bone structure in Proximal Femur. - Analysis by DXA-based 3D-modeling (3D-SHAPER Software) -TRIPLE-BONE study (The effects of TeRIParatide preparation on bone mineraL density increase and BONE structure).
Arch Osteoporos
; 19(1): 55, 2024 Jul 02.
Article
in En
| MEDLINE
| ID: mdl-38954145
ABSTRACT
Trends toward more favorable improvement of the cortical bone parameters by once-weekly (56.5 µg once a week) and twice-weekly teriparatide (28.2 µg twice a week), and that of the trabecular bone parameters by once-daily (1/D) teriparatide (20 µg/day once a day) were shown. PURPOSE:
To examine the effects of differences in the amount of teriparatide (TPTD) per administration and its dosing frequency on the bone structure in the proximal femur by dual-energy X-ray absorptiometry (DXA)-based 3D-modeling (3D-SHAPER software).METHODS:
This was a multicenter retrospective study. Patients aged 50 years or older with primary osteoporosis who continuously received once-/twice-weekly (1ã»2/W, n = 60) or 1/D TPTD (n = 14) administration for at least one year were included in the study. Measurement regions included the femoral neck (FN), trochanter (TR), femoral shaft (FS), and total proximal hip (TH). Concurrently, the bone mineral density (BMD) and Trabecular Bone Score (TBS) were measured.RESULTS:
The cross-sectional area, cross-sectional moment of inertia, and section modulus in the FS were significantly improved in the 1ã»2/W TPTD group, as compared to the 1/D TPTD group. However, significant improvement of the cortical thickness and buckling ratio in the FN was observed in the 1/D TPTD group, as compared to the 1ã»2/W TPTD group. Trabecular BMD values in the FS and TH were significantly increased in the 1/D TPTD group, as compared to the 1ã»2/W TPTD group, while the cortical BMD values in the TR, FS, and TH were significantly increased in the 1ã»2/W TPTD group, as compared to the 1/D TPTD group.CONCLUSION:
Trends toward more favorable improvement of the cortical bone by 1ã»2/W TPTD and that of the trabecular bones by 1/D TPTD were observed.Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Absorptiometry, Photon
/
Bone Density
/
Teriparatide
/
Imaging, Three-Dimensional
/
Bone Density Conservation Agents
/
Femur
Limits:
Aged
/
Aged80
/
Female
/
Humans
/
Male
/
Middle aged
Language:
En
Journal:
Arch Osteoporos
/
Archives of osteoporosis (Online)
Year:
2024
Document type:
Article
Affiliation country:
Japan
Country of publication:
United kingdom