A standardized approach to evaluate effectiveness of aerobic exercise training interventions in cardiovascular disease at the individual level.
Int J Cardiol
; 412: 132335, 2024 Oct 01.
Article
in En
| MEDLINE
| ID: mdl-38964557
ABSTRACT
BACKGROUND:
Reliable change indices can determine pre-post intervention changes at an individual level that are greater than chance or practice effect. We applied previously developed minimal meaningful change (MMCRCI) scores for oxygen uptake (VÌO2) values associated with estimated lactate threshold (θLT), respiratory compensation point (RCP), and peak oxygen uptake (VÌO2peak) to evaluate the effectiveness of exercise training in cardiovascular disease patients.METHODS:
303 patients (65 ± 11 yrs.; 27% female) that completed a symptom-limited cardiopulmonary exercise test (CPET) before and after 6-months of guideline-recommended exercise training were assessed to determine absolute and relative VÌO2 at θLT, RCP, and VÌO2peak. Using MMCRCI ∆VÌO2 scores of ±3.9 mL·kg-1·min-1, ±4.0 mL·kg-1·min-1, and ± 3.6 mL·kg-1·min-1 for θLT, RCP, and VÌO2peak, respectively, patients were classified as "positive" (ΔθLT, ΔRCP, and/or ΔVÌO2peak ≥ +MMCRCI), "non-" (between ±MMCRCI), or "negative" responders (≤ -MMCRCI).RESULTS:
Mean RCP (n = 86) and VÌO2peak (n = 303) increased (p < 0.05) from 19.4 ± 3.6 mL·kg-1·min-1 and 18.0 ± 6.3 mL·kg-1·min-1 to 20.1 ± 3.8 mL·kg-1·min-1 and 19.2 ± 7.0 mL·kg-1·min-1 at exit, respectively, whereas θLT (n = 140) did not change (15.5 ± 3.4 mL·kg-1·min-1 versus 15.7 ± 3.8 mL·kg-1·min-1, p = 0.324). For changes in θLT, 6% were classified as "positive" responders, 90% as "non-responders", and 4% as "negative" responders. For RCP, 10% exhibited "positive" changes, 87% were "non-responders", and 2% were "negative" responders. For ΔVÌO2peak, 57 patients (19%) were classified as "positive" responders, 229 (76%) as "non-responders", and 17 (6%) as "negative" responders.CONCLUSION:
Most patients that completed the exercise training program did not achieve reliable improvements greater than that of chance or practice at an individual level in θLT, RCP and VÌO2peak.Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Oxygen Consumption
/
Cardiovascular Diseases
/
Exercise Test
/
Exercise Therapy
Limits:
Aged
/
Female
/
Humans
/
Male
/
Middle aged
Language:
En
Journal:
Int J Cardiol
Year:
2024
Document type:
Article
Affiliation country:
Canada
Country of publication:
Netherlands